CDKN2A Protein (Fc Tag)

Catalog No. ABIN7491517

Product Details

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CDKN2A protein is labelled with Fc Tag.

Purpose: Recombinant Human p16 (11-40) Protein with N-terminal human Fc tag

Specificity: HFc (Glu99-Ala330) p16 (Pro11-Ala40)

Characteristics: Extracellular Domain Protein

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Alternative Name: p16 (CDKN2A Products)

Synonyms: Arf Protein, p16 Protein, MTS1 Protein, INK4A Protein, p19ARF Protein, p16Cdkn2a Protein, ARF Protein, CDK4I Protein, CDKN2 Protein, CMM2 Protein, INK4 Protein, MLM Protein, MTS-1 Protein, P14 Protein, P14ARF Protein, P16 Protein, P16-INK4A Protein, P16INK4 Protein, P16INK4A Protein, P19 Protein, P19ARF Protein, TP16 Protein, ARF-INK4a Protein, INK4a-ARF Protein, Ink4a/Arf Protein, Pctr1 Protein, p16(INK4a) Protein, p16INK4a Protein, p19 Protein, cyclin-dependent kinase inhibitor 2A Protein, cyclin dependent kinase inhibitor 2A Protein, Cdkn2a Protein, LOC100731972 Protein, LOC100340625 Protein, CDKN2A Protein

Background: CDKN2A, ARF, MLM, P14, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4AThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Molecular Weight: predicted molecular mass of 29.2 kDa after removal of the signal peptide. The apparent molecular mass of hFc-p16(11-40) is 25-35 kDa due to glycosylation.

UniProt: P42771

Pathways: Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus