Macrophage Mannose Receptor 1 Protein (Biotin,His tag)
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- Target See all Macrophage Mannose Receptor 1 (MRC1) Proteins
- Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Macrophage Mannose Receptor 1 protein is labelled with Biotin,His tag.
- Purpose
- Biotinylated Human CD206 / MMR Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
- Sequence
- Leu 19 - Ala 1389
- Characteristics
- Biotinylated Human CD206 Protein, His Tag, primary amine labeling is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Ala 1389 (Accession # P22897-1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
- Grade
- MALS verified
- Top Product
- Discover our top product MRC1 Protein
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Mannose Receptor, C Type 1 (MRC1) (AA 19-148) protein (His-IF2DI Tag)
MRC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Mannose Receptor, C Type 1 (MRC1) (AA 22-130) protein (GST tag)MRC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Mannose Receptor, C Type 1 (MRC1) (AA 19-1389) protein (His tag)Crystallography grade MRC1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 20-1388) protein (His tag)Crystallography grade MRC1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 19-1456) protein (rho-1D4 tag)Crystallography grade MRC1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 20-1456) protein (rho-1D4 tag)Crystallography grade MRC1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 19-1389) protein (His tag)MRC1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- Comment
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This protein carries a polyhistidine tag at the C-terminus. (Biotin,10xHis) The protein has a calculated MW of 158.6 kDa. The protein migrates as 170-210 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
- Alternative Name
- CD206 (MRC1 Products)
- Synonyms
- CD206 Protein, CLEC13D Protein, CLEC13DL Protein, MMR Protein, MRC1L1 Protein, bA541I19.1 Protein, AW259686 Protein, MR Protein, mrc1 Protein, MGC86525 Protein, MRC1 Protein, MRC1L-A Protein, mannose receptor C-type 1 Protein, mannose receptor, C type 1 Protein, mannose receptor C-type 1 L homeolog Protein, mediator of replication checkpoint 1 Protein, MRC1 Protein, Mrc1 Protein, mrc1.L Protein, mrc1 Protein
- Background
- Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
- Molecular Weight
- 158.6 kDa
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