HLA-A*02:01 (Monomer) protein (MAGE-A10)
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target
- HLA-A*02:01
- Protein Type
- Recombinant
- Protein Characteristics
- Monomer
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- MAGE-A10
- Purpose
- Human HLA-A*02:01 & B2M & MAGE-A10 (GLYDGMEHL) Monomer Protein
- Sequence
- Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and GLYDGMEHL peptide
- Specificity
- Uni-Prot: A0A140T913 (HLA-A*02:01), P61769 (B2M), GLYDGMEHL
- Characteristics
- Recombinant Human HLA-A*02:01 & B2M & MAGE-A10 (GLYDGMEHL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and GLYDGMEHL peptide.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- HLA-A*02:01
- Background
- MAGE-A10 is a subtype of the Melanoma-associated antigen A (MAGE-A), a class of tumor antigens that are extensively expressed in various histological types of tumors and represents an attractive target for tumor immunotherapy. High-level expression of MAGE-A10 improved the anti-tumor immune cytotoxicity of MAGE-A10-specific CTLs in lung cancer cell lines and primary lung cancer cells.
- Molecular Weight
- 50.44 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A140T913
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