LY6G6D Protein (AA 20-104) (Fc Tag)

Catalog No. ABIN7504464

Product Details

Target: LY6G6D (Lymphocyte Antigen 6 Complex, Locus G6D (LY6G6D))

Protein Type: Recombinant

Protein Characteristics: AA 20-104

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LY6G6D protein is labelled with Fc Tag.

Purpose: Human LY6G6D Protein

Sequence: Asn20-Ser104

Characteristics: Recombinant Human LY6G6D Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Asn20-Ser104.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: LY6G6D (Lymphocyte Antigen 6 Complex, Locus G6D (LY6G6D))

Alternative Name: LY6G6D (LY6G6D Products)

Synonyms: C6orf23 Protein, G6D Protein, LY6-D Protein, MEGT1 Protein, NG25 Protein, A930024F17Rik Protein, G6d Protein, G6f Protein, NG32 Protein, Ly6-D Protein, Ng25 Protein, lymphocyte antigen 6 family member G6D Protein, lymphocyte antigen 6 complex, locus G6D Protein, LY6G6D Protein, Ly6g6d Protein

Background: LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.

Molecular Weight: 35.87 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

UniProt: O95868