IFNAR1 Protein (AA 28-200) (His tag)

Catalog No. ABIN7504932

Product Details

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Protein Type: Recombinant

Protein Characteristics: AA 28-200

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This IFNAR1 protein is labelled with His tag.

Sequence: Lys28-Leu200

Characteristics: A DNA sequence encoding the Human IFNAR1 (P17181-1) (Lys28-Leu200) was expressed with a polyhistidine tag at the N-terminus.

Purity: >85 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFNAR1 (IFNAR1 Products)

Synonyms: ifnar1 Protein, IFNAR1 Protein, CD118 Protein, Ifar Protein, Ifnar Protein, Ifrc Protein, Infar Protein, AVP Protein, IFN-alpha-REC Protein, IFNAR Protein, IFNBR Protein, IFRC Protein, IFN-R-1 Protein, interferon alpha and beta receptor subunit 1 Protein, interferon-alpha/beta receptor alpha chain-like Protein, interferon (alpha and beta) receptor 1 Protein, interferon alpha/beta receptor 1 Protein, IFNAR1 Protein, ifnar1 Protein, Ifnar1 Protein, LOC609830 Protein

Background:

Background: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2 . Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

Synonym: Interferon alpha/beta receptor 1,IFN-R-1 IFN-alpha/beta receptor 1,Cytokine receptor class-II member 1,Cytokine receptor family 2 member 1,CRF2-1,Type I interferon receptor 1,IFNAR

Molecular Weight: 20 kDa

Pathways: JAK-STAT Signaling, Hepatitis C