CDNF Protein (His tag)
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- Target See all CDNF Proteins
- CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CDNF protein is labelled with His tag.
- Purpose
- Recombinant Human Cerebral dopamine neurotrophic factor/CDNF Protein
- Sequence
- QEAGGRPGAD CEVCKEFLNR FYKSLIDRGV NFSLDTIEKE LISFCLDTKG KENRLCYYLG ATKDAATKIL SEVTRPMSVH MPAMKICEKL KKLDSQICEL KYEKTLDLAS VDLRKMRVAE LKQILHSWGE ECRACAEKTD YVNLIQELAP KYAATHPKTE L
- Specificity
- Gln27-Leu187
- Purity
- > 97 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- <0.001EU/μg
- Top Product
- Discover our top product CDNF Protein
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Cerebral Dopamine Neurotrophic Factor (CDNF) (AA 25-187) protein (His tag)
CDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cerebral Dopamine Neurotrophic Factor (CDNF) protein (His tag)CDNF Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Cerebral Dopamine Neurotrophic Factor (CDNF) (AA 25-187) protein (His tag)Crystallography grade CDNF Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cerebral Dopamine Neurotrophic Factor (CDNF) (AA 25-187) protein (His tag)Crystallography grade CDNF Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Concentration
- 1.26 mg/mL
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- Target
- CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))
- Alternative Name
- Cerebral dopamine neurotrophic factor/CDNF (CDNF Products)
- Synonyms
- ARMETL1 Protein, 9330140G23 Protein, Armetl1 Protein, cerebral dopamine neurotrophic factor Protein, CDNF Protein, Cdnf Protein
- Background
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Description: Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
Name: ARMETL1,Cerebral dopamine neurotrophic factor,CDNF
- Gene ID
- 441549
- UniProt
- Q49AH0
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