CHI3L1 Protein (His tag)

Catalog No. ABIN7535837

Product Details

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CHI3L1 protein is labelled with His tag.

Purpose: Recombinant Mouse YKL-40/CHI3L1 Protein

Sequence: YKLVCYFTSW SQYREGVGSF LPDAIQPFLC THIIYSFANI SSDNMLSTWE WNDESNYDKL NKLKTRNTNL KTLLSVGGWK FGEKRFSEIA SNTERRTAFV RSVAPFLRSY GFDGLDLAWL YPRLRDKQYF STLIKELNAE FTKEVQPGRE KLLLSAALSA GKVAIDTGYD IAQIAQHLDF INLMTYDFHG VWRQITGHHS PLFQGQKDTR FDRYSNVNYA VQYMIRLGAQ ASKLLMGIPT FGKSFTLASS ENQLGAPISG EGLPGRFTKE AGTLAYYEIC DFLKGAEVHR LSNEKVPFAT KGNQWVGYED KESVKNKVGF LKEKKLAGAM VWALDLDDFQ GTCQPKEFFP LTNAIKDALA

Specificity: Tyr30-Ala389

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Alternative Name: YKL-40/CHI3L1 (CHI3L1 Products)

Synonyms: AW208766 Protein, Brp39 Protein, Gp39 Protein, ASRT7 Protein, CGP-39 Protein, GP-39 Protein, GP39 Protein, HC-gp39 Protein, HCGP-3P Protein, YKL-40 Protein, YKL40 Protein, YYL-40 Protein, hCGP-39 Protein, GP38K Protein, CLP-1 Protein, SPC-40 Protein, SPS-40 Protein, Chil1 Protein, BP40 Protein, MGP-40 Protein, chitinase-like 1 Protein, chitinase 3 like 1 Protein, chitinase 3-like 1 (cartilage glycoprotein-39) Protein, Chil1 Protein, CHI3L1 Protein, Chi3l1 Protein

Background:

Description: Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

Name: CHI3L1,YKL-40,CGP-39,GP-39,ASRT7,CHI3L1

Gene ID: 12654

UniProt: Q61362