FABP4 Protein (His tag)

Catalog No. ABIN7519975

Product Details

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FABP4 protein is labelled with His tag.

Purpose: Recombinant Mouse FABP4/A-FABP/ALBP Protein

Sequence: CDAFVGTWKL VSSENFDDYM KEVGVGFATR KVAGMAKPNM IISVNGDLVT IRSESTFKNT EISFKLGVEF DEITADDRKV KSIITLDGGA LVQVQKWDGK STTIKRKRDG DKLVVECVMK GVTSTRVYER A

Specificity: Cys2-Ala132

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Alternative Name: FABP4/A-FABP/ALBP (FABP4 Products)

Synonyms: A-FABP Protein, AFABP Protein, ALBP Protein, aP2 Protein, LOC100223994 Protein, FABP Protein, AP2 Protein, FABP3 Protein, FABP4 Protein, MGC84940 Protein, fabp4 Protein, 422/aP2 Protein, ALBP/Ap2 Protein, Ap2 Protein, Lbpl Protein, Albp Protein, fatty acid binding protein 4 Protein, fatty acid-binding protein, adipocyte Protein, fatty acid binding protein 4, adipocyte Protein, fatty acid binding protein 4, adipocyte L homeolog Protein, Fatty acid-binding protein, adipocyte Protein, adipocyte fatty acid-binding protein Protein, adipocyte fatty acid binding protein Protein, FABP4 Protein, LOC100223994 Protein, fabp4.L Protein, fabp4 Protein, Fabp4 Protein, LOC100732353 Protein, LOC100861279 Protein, LOC100057425 Protein, LOC395224 Protein

Background:

Description: Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

Name: Ap2,P15,ALBP,Lbpl,AFABP,422/aP2,ALBP/Ap2,FABP4

Gene ID: 11770

UniProt: P04117

Pathways: Brown Fat Cell Differentiation