IL-11 Protein
Quick Overview for IL-11 Protein (ABIN7533816)
Target
See all IL-11 (IL11) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Active Recombinant Human IL-11 Protein
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Sequence
- PGPPPGPPRV SPDPRAELDS TVLLTRSLLA DTRQLAAQLR DKFPADGDHN LDSLPTLAMS AGALGALQLP GVLTRLRADL LSYLRHVQWL RRAGGSSLKT LEPELGTLQA RLDRLLRRLQ LLMSRLALPQ PPPDPPAPPL APPSSAWGGI RAAHAILGGL HLTLDWAVRG LLLLKTRL
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Specificity
- Pro22-Leu199
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- < 1.0 EU/μg of the protein by LAL method.
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Biological Activity Comment
- Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 1.3-5 ng/mL, corresponding to a specific activity of 2x105-7.69x105units/mg.
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Interleukin 11 (IL11) (AA 22-199) protein (His tag)
IL11 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 11 (IL11) (AA 22-199) protein (His tag)IL11 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 11 (IL11) (AA 22-199) (Active) protein (His tag)IL11 Origin: Human Host: Escherichia coli (E. coli) > 90 % CC, AcA Active
Interleukin 11 (IL11) (Active) proteinIL11 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 11 (IL11) protein (Fc Tag)IL11 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 11 (IL11) (AA 22-199) (Active) protein (His tag)IL11 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
Interleukin 11 (IL11) (AA 22-199) (Active) protein (His tag)IL11 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active
Interleukin 11 (IL11) (AA 1-199) protein (GST tag)IL11 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 11 (IL11) proteinIL11 Origin: Human Host: Escherichia coli (E. coli) Recombinant 95,00% SDS
Interleukin 11 (IL11) (AA 22-199) (Active) protein (His tag)IL11 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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Buffer
- Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.
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Storage
- -20 °C,-80 °C
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Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- IL-11 (IL11) (Interleukin 11 (IL11))
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Alternative Name
- IL-11
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Background
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Description: The protein is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
Name: IL11,AGIF,IL-11
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Gene ID
- 3589
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UniProt
- P20809
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Pathways
- JAK-STAT Signaling, Negative Regulation of Hormone Secretion
Target
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