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IL12 Protein

Recombinant IL12 protein expressed in HEK-293 Cells.
Catalog No. ABIN7536200

Quick Overview for IL12 Protein (ABIN7536200)

Target

See all IL12 Proteins
IL12 (Interleukin 12 (IL12))

Protein Type

Recombinant

Biological Activity

Active

Origin

  • 22
  • 14
  • 4
  • 1
Mouse

Source

  • 16
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
HEK-293 Cells
  • Purpose

    Active Recombinant Mouse IL-12A&IL-12B Protein

    Sequence

    RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA&MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS

    Specificity

    Arg23-Ala215,Met23-Ser335

    Sterility

    0.22 μm filtered

    Endotoxin Level

    <0.1EU/μg

    Biological Activity Comment

    1.Measured by its binding ability in a functional ELISA.Immobilized Mouse IL-12A&IL-12B at 5 μg/mL (100 μL/well) can bind Human IL12RB1 with a linear range of 0.001-3.3 ng/mL.|2.Active Recombinant Mouse IL-12(Cat. RP01691)induces the mouse T cells differentiate into Th1 cells. Flow cytometry was used to detect the expression of IFN-γ. Result showed that Th1 cells were induced successfully.(Customer Feedback Data).
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

    Buffer

    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • Target

    IL12 (Interleukin 12 (IL12))

    Alternative Name

    IL-12A&IL-12B

    Background

    Description: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.

    Name: p35, Ll12a, Il-12a, IL-12p35&p40, Il-12b, Il12p40, Il-12p40,IL-12&Il12b,IL-12 p70(IL12A&IL12B)

    Gene ID

    16159

    UniProt

    P43431, P43432

    Pathways

    JAK-STAT Signaling, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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