KNG1 Protein (His tag)
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- Target See all KNG1 Proteins
- KNG1 (Kininogen 1 (KNG1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KNG1 protein is labelled with His tag.
- Purpose
- Active Recombinant Human Kininogen-1/KNG1 Protein
- Sequence
- QESQSEEIDC NDKDLFKAVD AALKKYNSQN QSNNQFVLYR ITEATKTVGS DTFYSFKYEI KEGDCPVQSG KTWQDCEYKD AAKAATGECT ATVGKRSSTK FSVATQTCQI TPAEGPVVTA QYDCLGCVHP ISTQSPDLEP ILRHGIQYFN NNTQHSSLFM LNEVKRAQRQ VVAGLNFRMT YSIVQTNCSK ENFLFLTPDC KSLWNGDTGE CTDNAYIDIQ LRIASFSQNC DIYPGKDFVQ PPTKICVGCP RDIPTNSPEL EETLTHTITK LNAENNATFY FKIDNVKKAR VQVVAGKKYF IDFVARETTC SKESNEELTE SCETKKLGQS LDCNAEVYVV PWEKKIYPTV NCQPLGMISL MKRPPGFSPF RSSRIGEIKE ETTSHLRSCE YKGRPPKAGA EPASEREVS
- Specificity
- Gln19-Ser427
- Purity
- > 97 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC. The IC50 value approximately is 1 nM.
- Top Product
- Discover our top product KNG1 Protein
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Kininogen 1 (KNG1) (AA 19-380) protein (His tag)
KNG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Kininogen 1 (KNG1) (AA 1-427) protein (GST tag)KNG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (AA 322-427) protein (GST tag)KNG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (Active) protein (His tag)KNG1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- Target
- KNG1 (Kininogen 1 (KNG1))
- Alternative Name
- Kininogen-1/KNG1 (KNG1 Products)
- Synonyms
- BDK Protein, BK Protein, KNG Protein, Kng Protein, KNG2 Protein, fb64g01 Protein, wu:fb64g01 Protein, zgc:103569 Protein, kininogen Protein, bdk Protein, kng Protein, KNG1 Protein, IHRP Protein, KINKG Protein, KINKH Protein, Kng1 Protein, Kngk Protein, kininogen 1 Protein, kininogen 1 L homeolog Protein, inter-alpha-trypsin inhibitor heavy chain family member 4 Protein, kininogen 2-like 1 Protein, KNG1 Protein, Kng1 Protein, kng1 Protein, kng1.L Protein, ITIH4 Protein, Kng2l1 Protein
- Background
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Description: Kininogen-1 (KNG1) is also known as high molecular weight kininogen, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, Williams-Fitzgerald-Flaujeac factor, which can be cleaved into the following 6 chains:Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor. Kininogen-1 is a secreted protein which contains three cystatin domains. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed.Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.
Name: BDK, BK, KNG,KNG1,BK,KNG
- Gene ID
- 3827
- UniProt
- P01042-2
- Pathways
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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