MFGE8 Protein (His tag)

Catalog No. ABIN7535664

Product Details

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This MFGE8 protein is labelled with His tag.

Purpose: Recombinant Mouse MFG-E8 Protein

Sequence: ASGDFCDSSL CLNGGTCLTG QDNDIYCLCP EGFTGLVCNE TERGPCSPNP CYNDAKCLVT LDTQRGDIFT EYICQCPVGY SGIHCETETN YYNLDGEYMF TTAVPNTAVP TPAPTPDLSN NLASRCSTQL GMEGGAIADS QISASSVYMG FMGLQRWGPE LARLYRTGIV NAWTASNYDS KPWIQVNLLR KMRVSGVMTQ GASRAGRAEY LKTFKVAYSL DGRKFEFIQD ESGGDKEFLG NLDNNSLKVN MFNPTLEAQY IKLYPVSCHR GCTLRFELLG CELHGCSEPL GLKNNTIPDS QMSASSSYKT WNLRAFGWYP HLGRLDNQGK INAWTAQSNS AKEWLQVDLG TQRQVTGIIT QGARDFGHIQ YVASYKVAHS DDGVQWTVYE EQGSSKVFQG NLDNNSHKKN IFEKPFMARY VRVLPVSWHN RITLRLELLG C

Specificity: Ala23-Cys463

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Alternative Name: MFG-E8 (MFGE8 Products)

Synonyms: BA46 Protein, EDIL1 Protein, HMFG Protein, HsT19888 Protein, MFG-E8 Protein, MFGM Protein, OAcGD3S Protein, SED1 Protein, SPAG10 Protein, hP47 Protein, ba46 Protein, edil1 Protein, oacgd3s Protein, MGC75581 Protein, hst19888 Protein, MGC145109 Protein, MFGE8 Protein, mfge8 Protein, zgc:154157 Protein, MGC99228 Protein, AA408458 Protein, AI325141 Protein, Mfgm Protein, P47 Protein, lactadherin Protein, AGS Protein, MFGME8 Protein, MFGMP-E8 Protein, im:6895406 Protein, mfge8l Protein, zgc:110846 Protein, milk fat globule-EGF factor 8 protein Protein, milk fat globule-EGF factor 8 protein b Protein, milk fat globule-EGF factor 8 protein L homeolog Protein, milk fat globule-EGF factor 8 protein a Protein, MFGE8 Protein, mfge8 Protein, mfge8b Protein, mfge8.L Protein, Mfge8 Protein, mfge8a Protein

Background:

Description: MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. It binds PS, which is exposed on the surface of apoptotic cells. MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. Overexpression of MFG-E8 can be found in several carcinomas. MFG-E8 has opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. It promotes VEGF-dependent neovascularization and contributes to the phagocytic removal of apoptotic cells in many tissues. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.

Name: P47,MP47,Mfgm,SED1,MFG-E8,AA408458,AI325141,lactadherin,MFGE8

Gene ID: 17304

UniProt: P21956-1

Pathways: SARS-CoV-2 Protein Interactome