SIRPB1 Protein (His tag)
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- Target See all SIRPB1 Proteins
- SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SIRPB1 protein is labelled with His tag.
- Purpose
- Recombinant Human SIRP-beta-1/SIRPB1/CD172b Protein
- Sequence
- EDELQVIQPE KSVSVAAGES ATLRCAMTSL IPVGPIMWFR GAGAGRELIY NQKEGHFPRV TTVSELTKRN NLDFSISISN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAVRA TPEHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP AGDSVSYSIH STARVVLTRG DVHSQVICEI AHITLQGDPL RGTANLSEAI RVPPTLEVTQ QPMRAENQAN VTCQVSNFYP RGLQLTWLEN GNVSRTETAS TLIENKDGTY NWMSWLLVNT CAHRDDVVLT CQVEHDGQQA VSKSYALEIS AHQKEHGSDI THEAALAPTA PL
- Specificity
- Glu30-Leu371
- Purity
- > 95 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- <0.1EU/μg
- Top Product
- Discover our top product SIRPB1 Protein
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Signal-Regulatory Protein beta 1 (SIRPB1) (AA 30-371), (Isoform 3) protein (His-Avi Tag)
SIRPB1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Signal-Regulatory Protein beta 1 (SIRPB1) (AA 30-371), (Isoform 3) protein (His-Avi Tag,Biotin)SIRPB1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Signal-Regulatory Protein beta 1 (SIRPB1) (AA 1-181) protein (GST tag)SIRPB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Signal-Regulatory Protein beta 1 (SIRPB1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SIRPB1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- Target
- SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))
- Alternative Name
- SIRP-beta-1/SIRPB1/CD172b (SIRPB1 Products)
- Synonyms
- CD172b Protein, SIRP-BETA-1 Protein, SIRPB1 Protein, SIRPG Protein, signal regulatory protein beta 1 Protein, signal-regulatory protein beta-1 Protein, signal-regulatory protein beta-1 isoform 3 Protein, SIRPB1 Protein, LOC458036 Protein, LOC458430 Protein, LOC485809 Protein, LOC715912 Protein, LOC100458151 Protein
- Background
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Description: Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRP1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily.Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.
Name: 9930027N05Rik,SIRP-beta,Sirpb,Sirpb1,SIRPB1
- Gene ID
- 10326
- UniProt
- O00241
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