Glucagon Receptor Protein (GCGR) (AA 26-136) (Fc Tag)
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- Target See all Glucagon Receptor (GCGR) Proteins
- Glucagon Receptor (GCGR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-136
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Glucagon Receptor protein is labelled with Fc Tag.
- Purpose
- Human GCGR/Glucagon receptor Protein
- Sequence
- Ala26-Lys136
- Characteristics
- Recombinant Human GCGR/Glucagon receptor Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ala26-Lys136.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product GCGR Protein
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Glucagon Receptor (GCGR) protein
GCGR Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Glucagon Receptor (GCGR) (AA 26-136) protein (Fc Tag)GCGR Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Glucagon Receptor (GCGR) (AA 26-136) protein (His tag)GCGR Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Glucagon Receptor (GCGR)
- Alternative Name
- GCGR (GCGR Products)
- Background
- The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
- Molecular Weight
- 39.00 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
- UniProt
- P47871
- Pathways
- Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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