Glucagon Receptor Protein (GCGR) (AA 26-136) (His-Avi Tag)

Catalog No. ABIN7583262

Product Details

Target: Glucagon Receptor (GCGR)

Protein Type: Recombinant

Protein Characteristics: AA 26-136

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Glucagon Receptor protein is labelled with His-Avi Tag.

Purpose: Human GCGR/Glucagon receptor Protein

Sequence: Ala26-Lys136

Characteristics: Recombinant Human GCGR/Glucagon receptor Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ala26-Lys136.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Glucagon Receptor (GCGR)

Alternative Name: GCGR (GCGR Products)

Background: The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.

Molecular Weight: 15.96 kDa. Due to glycosylation, the protein migrates to 30-50 kDa based on Tris-Bis PAGE result.

UniProt: P47871

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process