BDNF Protein

Catalog No. ABIN7849701

Recombinant BDNF protein expressed in Escherichia coli (E. coli).

Quick Overview for BDNF Protein (ABIN7849701)

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: >95 % by SDS-PAGE

Product Details

Purpose: Recombinant Human /Mouse/Rat BDNF Protein

Sterility: 0.2 μm filtered

Endotoxin Level: <0.01EU/μg by LAL test

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration <100 μg/mL.)

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 400 mM NaCl, pH 7.2.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Target Details

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Alternative Name: BDNF

Background:

Synonyms: Brain-derived neurotrophic factor, BDNF, brain-derived neurotrophic factor, ANON2, BULN2, brain derived neurotrophic factor

Description: Recombinant human BDNF is produced by the E.coli system, with the target gene encoding His129-Arg247 expressed.

Background: Brain-derived neurotrophic factor, also known as BDNF, is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. BDNF is a member of the "neurotrophin" family of growth factors, which are related to the NGF. It acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. In the brain, it is active in the hippocampus, cortex, and basal forebrain-areas vital to learning, memory, and higher thinking. Post mortem analysis has shown lowered levels of BDNF in the brain tissues of people with Alzheimer's disease.

UniProt: P23560

Pathways: RTK Signaling, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity