CDK2 Protein
Quick Overview for CDK2 Protein (ABIN7938736)
Target
See all CDK2 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CDK2 protein
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Cyclin-Dependent Kinase 2 (CDK2) (AA 1-346) protein (His tag)
custom-made CDK2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) protein (His tag)custom-made CDK2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) protein (GST tag)CDK2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) protein (His tag)CDK2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CDK2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
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Alternative Name
- CDK2
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Background
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Protein Background: CDK2 (Cyclin-dependent kinase 2) , also known as CDKN2 and p33(CDK2)CDKN2 is a serine/threonineprotein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs).
Short Description: Recombinant CDK2 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001789.2) with an C-terminal FLAG tag. The molecular weight of CDK2 is 35.62 kDa.
Aliases: CDKN2, p33(CDK2), Cell Division Protein Kinase 2, P33(CDK2)
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Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
Target
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