EPH Receptor B4 Protein (EPHB4) (AA 561-987)

Catalog No. ABIN7938807

This Recombinant EPH Receptor B4 protein is produced in Baculovirus infected Insect Cells.

Quick Overview for EPH Receptor B4 Protein (EPHB4) (AA 561-987) (ABIN7938807)

Target: EPH Receptor B4 (EPHB4)

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Screening Assay (ScA), Functional Studies (Func), Activity Assay (AcA)

Product Details

Protein Characteristics: AA 561-987

Purpose: Recombinant EPHB4 (561-987) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant EPHB4 (561-987) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: EPH Receptor B4 (EPHB4)

Alternative Name: EPHB4

Background:

Protein Background: EPHB4(Ephrin type-B receptor 4) is a Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/ functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

Short Description: Recombinant EPHB4 (561-987) protein that includes amino acids 561-987 of human EPHB4 protein (accession number NP_004435.3) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.89 kDa.

Aliases: Ephrin type-B receptor 4, TYRO11, HTK, MYK1, Tyrosine-Protein Kinase Receptor HTK

Pathways: RTK Signaling