eIF4EBP1 Protein
Quick Overview for eIF4EBP1 Protein (ABIN7938835)
Target
See all eIF4EBP1 (EIF4EBP1) ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant EIF4EBP1 protein
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Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (GST tag)
EIF4EBP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (His tag)EIF4EBP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) protein (His tag)EIF4EBP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant EIF4EBP1 protein is supplied in 25 mM Tris pH 7.4, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
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Alternative Name
- EIF4EBP1
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Background
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Protein Background: EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1 ) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Short Description: Recombinant EIF4EBP1 protein was expressed in E.coli as the full length protein (accession number NP_004086.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 14.51 kDa.
Aliases: Eukaryotic translation initiation factor 4E-binding protein 1,also known as 4E-BP1 or eIF4Ebinding protein 1
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Pathways
- MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling
Target
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