TCEB2 Protein (AA 1-118)
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- Target See all TCEB2 Proteins
- TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-118
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Sequence
- MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ
- Characteristics
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Purified recombinant Human Elongin B protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - Purity
- > 95 % pure
- Top Product
- Discover our top product TCEB2 Protein
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- Application Notes
- Elongin B protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 0 mM DTT, 0.0 mM PMSF, and 20 % glycerol.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
- Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- Target
- TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))
- Alternative Name
- Elongin B (TCEB2 Products)
- Synonyms
- 0610040H15Rik Protein, cb162 Protein, wu:fb47e08 Protein, ELOB Protein, SIII Protein, elongin B Protein, Elob Protein, elob Protein, ELOB Protein
- Background
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Elongin B , also known as TCEB2, is a subunit of the transcription factor B (SIII) complex. The SIII complex is a heterotrimer consisting of a transcriptionally active subunit (A) and two regulatory subunits (B and C). It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C, and thereby inhibits transcription elongation. Recombinant TCEB2 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Alternative Names: Elongin B protein, Transcription elongation factor B polypeptide 2 protein, Elongin 18 kDa subunit protein, SIII p18 protein, TCEB 2 protein, EloB protein, EloB protein, RNA polymerase II transcription factor SIII subunit B protein, Transcription elongation factor B (SIII) polypeptide 2., TCEB2 protein - Molecular Weight
- 13.1 kDa (118 AA)
- Pathways
- SARS-CoV-2 Protein Interactome
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