TNFRSF13C Protein

Catalog No. ABIN987764

Product Details

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLP

Characteristics: Fully biologically active when compared to standard. Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 1.0-5.0 µg/ml in the presence of 1.0µg/ml of human soluble BAFF,corresponding to a specific activity of > 2.0×102 units/mg.

Purity: > 95 % by reduced SDS-PAGE analyses.

Endotoxin Level: Level Less than 1EU/µg of rHuBAFF-R as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Alternative Name: BAFF Receptor (BAFF-R) (TNFRSF13C Products)

Synonyms: RGD1560810 Protein, TNFRSF13C Protein, BAFF-R Protein, BAFFR Protein, BROMIX Protein, CD268 Protein, CVID4 Protein, prolixin Protein, 2010006P15Rik Protein, Baffr Protein, Bcmd Protein, Bcmd-1 Protein, Bcmd1 Protein, Lvis22 Protein, TNF receptor superfamily member 13C Protein, uncharacterized LOC746611 Protein, tumor necrosis factor receptor superfamily, member 13c Protein, TNFRSF13C Protein, Tnfrsf13c Protein, LOC746611 Protein

Background: BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Synonym: BAFF Receptor ( BAFF-R), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 8.0, 500mM NaCl.

Molecular Weight: Approximately 7.7 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.

Pathways: NF-kappaB Signaling