CXCL2 Protein

Catalog No. ABIN988160

Product Details

Target: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Biological Activity: Active

Origin: Mouse

Source: Escherichia coli (E. coli)

Sequence: AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KA

Characteristics: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human neutrophils is less than 10 ng/ml, corresponding to a specific activity of >, 1.0 × 105 IU/mg.

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Endotoxin Level: Level Less than 1EU/µg of rMuMIP-2/CXCL2 as determined by LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Storage: 4 °C

Target Details

Target: CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))

Alternative Name: MIP-2/CXCL2 (CXCL2 Products)

Synonyms: CINC-2a Protein, GRO2 Protein, GROb Protein, MGSA-b Protein, MIP-2a Protein, MIP2 Protein, MIP2A Protein, SCYB2 Protein, GRO3 Protein, Gro2 Protein, MIP-2 Protein, Mgsa-b Protein, Mip2 Protein, Scyb Protein, Scyb2 Protein, Mip-2 Protein, GROB Protein, MIP-2alpha Protein, C-X-C motif chemokine ligand 2 Protein, chemokine (C-X-C motif) ligand 2 Protein, CXCL2 Protein, Cxcl2 Protein

Background: Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a mouse macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC) subfamily of chemokines.Similarly to other alpha chemokines, mouse MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the mouse interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases. Synonym: MIP-2/CXCL2, Mouse. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Molecular Weight: 7.8 kDa, a single, non-glycosylated polypeptide chain containing 73 amino acids.

Pathways: Cellular Response to Molecule of Bacterial Origin