Browse our anti-Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 4 (SLC25A4) Antibodies

Human Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 4 (SLC25A4) interaction partners

1. The findings underscore the central role played by ANT in the control of oxidative phosphorylation, particularly at the energy phosphate levels associated with low ATP demand. As predicted by molecular dynamic modeling, ANT Lysine23 acetylation decreased the apparent affinity of ADP for ANT binding.

2. Patients with SLC25A4 (ANT1) gene mutations present a common phenotype with exercise intolerance, hyperlactatemia, and hypertrophic cardiomyopathy.

3. NF-kappaB signalling may repress ANT1 gene transcription and impair mitochondrial functions.

4. Data indicate that by inhibiting adenine nucleotide translocase 1 (ANT1) and mitochondrial dysfunction, tyrosine phosphatase SHP2 orchestrates an intrinsic regulatory loop to limit excessive NLR family, pyrin domain-containing 3 protein (NLRP3) inflammasome activation.

5. ANT1 confers sensitivity of the mitochondrial permeability transition pore to the electrochemical gradient.

6. These findings suggest that DRAK1 translocates in response to stimuli and induces apoptosis through its interaction with specific binding partners, p53 and/or ANT2.

7. Yeast aac2 R96H and aac2 R252G mutations are equivalent to R80H and R235G human ANT1 pathological mutations. mtDNA instability induced by aac2R96H and aac2R252G is rescued by N-acetylcysteine.

8. identification by whole-exome sequencing of seven probands harboring dominant, de novo SLC25A4 mutations; all affected individuals presented at birth, were ventilator dependent and, where tested, revealed severe combined mitochondrial respiratory chain deficiencies associated with a marked loss of mitochondrial DNA copy number in skeletal muscle

9. A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT).

10. Identification of ZNF555 as a putative transcriptional factor that impacts ANT1 promoter activity in facioscapulohumeral dystrophy myoblasts.

11. elevated ANT1 expression supports EV infection and is associated with EV persistence, a condition with adverse prognosis.

12. Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function.

13. Data suggest acetylation of ANT1 at lysines 10/23/92 has dramatic physiological effects on ADP-ATP exchange; extent of acetylation of lysine 23 decreases following physical activity; this change is highly dependent on insulin sensitivity/resistance.

14. Expression of ANT1 were lower in inclusion body myositis samples versus both polymyositis and controls

15. Compares and contrasts all the known human SLC25A* genes and includes functional information.

16. A 13-generation Mennonite pedigree with autosomal recessive myopathy and cardiomyopathy due to an SLC25A4 frameshift null mutation (c.523delC, p.Q175RfsX38), which codes for the heart-muscle isoform of the adenine nucleotide translocator-1, was studied.

17. This report expands the clinical spectrum of ANT1-related human diseases, and emphasises the crucial role of the mitochondrial ADP/ATP carriers in muscle function and pathophysiology of human myopathies.

18. mutant human ANT1 causes dominant mitochondrial defects characterized by decreased ADP-ATP exchange function and abnormal translocator reversal potential

19. There was no significant difference in slc25a4 mRNA expression between the AML patients with complete remission and those without remission.

20. The respiratory-dependent assembly of ANT1 differentially regulates Bax and Ca2+ mediated cytochrome c release.

Mouse (Murine) Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 4 (SLC25A4) interaction partners

1. The ANT1-deficient muscle mitochondria produce excess reactive oxygen species (ROS) and are partially uncoupled. Hence, the muscle respiration under nonphosphorylating conditions is increased. Muscle transcriptome analysis revealed the induction of mitochondrial biogenesis, down-regulation of diabetes-related genes, and increased expression of the genes encoding the myokines FGF21 and GDF15.

2. ANT1 can induce autoimmune myocarditis in A/J mice by generating autoreactive T cells.

3. miR-2861 and ANT1 are regulators of cardiomyocyte necrosis and myocardial infarction.

4. These results suggest that follicular helper T cells cells and IL-21 might be involved in the pathogenesis of viral myocarditis and play an important role in anti-ANT autoantibody production.

5. Data indicate that palmitoyl-carnitine (PC) increases the type 2 ryanodine receptor (RyR2) oxidation and reduces the ATP/ADP translocase (ANT) activity.

6. Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-alpha-mediated cardiac inflammatory responses.

7. Its mutation causes some inherited Parkinson disease.

8. Plasma membrane-localized ANT1 and ANT2 regulate L1-mediated neurite outgrowth in conjunction with MMP14.

9. Although the molecular mechanism linking ANT1-Cys(57) nitroalkylation and uncoupling is not yet known, these data suggest that ANT1-mediated uncoupling may be a mechanism for nitroalkene-induced cardioprotection.

10. The attenuation of ANT-1 in the presence of PGC-1alpha overexpression preserves the mitochondrial membrane potential in response to hydrogen-peroxide stress.

11. Data demonstrate that ANT1 protein levels are upregulated in Mecp2-null mice.

12. uncoupling protein-3 can minimize the induction of the adenine nucleotide translocase-mediated 'energy-wasting' process during Calorie restriction (CR).

13. The astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake

14. ANTs are non-essential structural components of the mitochondrial permeability transition pore, although they do contribute to its regulation

15. half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions

16. The ANT1 isoform may mediate a significant part of the high basal proton leak in brown-fat mitochondria.

17. The Ant1 deficient mouse skeletal muscle demonstrates that energy metabolism, antioxidant defenses, and apoptosis form an integrated metabolic network.

18. Cardiomyocyte-restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic cardiomyopathy.

19. Inhibition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury

20. The mitochondrial membrane potential of Ant1-deficient brain mitochondria is increased and the permeability transition pore is more resistant to calcium induced permeability transition.

Cow (Bovine) Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 4 (SLC25A4) interaction partners

1. Data show that the binding sites on adenine nucleotide translocator 1 (ANT1) have an affinity for cardiolipin (CL).

2. Phosphatidic acid and cardiolipin interact with the mitochondrial ADP/ATP carrier.

3. Crystal form of ADP/ATP carrier obtained in the presence of carboxyatractyloside was analysed.