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Human SLC9A3R1 Protein expressed in HEK-293 Cells - ABIN2732190
Wang, Qin, Zhu: Expression of Na+/H+ exchanger regulatory factor 1 in autosomal-dominant polycystic kidney disease. in The Journal of international medical research 2015
The up-regulation of NHERF1 induced by the exposure to hypoxia in colon cancer cells depends on the activation of VEGFR2 (show KDR Proteins) signaling.
-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1 (show RASSF1 Proteins), isoform A (RASSF1A (show RASSF1 Proteins)) inactivation in liver metastases.
Na+/H+ exchanger regulatory factor (NHERF1) expression level positively associates with G protein-coupled estrogen receptor (GPER) activation in ER-positive breast cancer.
The present results suggest a role for NHERF1 in the progression of breast cancer mediated by the nuclear distribution of the NHERF1 protein, as determined by the truncation or key site mutation of the PDZ-I domain.
NF2 (show NF2 Proteins) localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 (show NF2 Proteins) to TIMAP (show PPP1R16B Proteins) and EBP50 is critical in nuclear localization of NF2 (show NF2 Proteins). (NF2 (show NF2 Proteins) = neurofibromin 2 (show NF2 Proteins); TIMAP (show PPP1R16B Proteins) = TGF-beta-inhibited membrane-associated protein (show PPP1R16B Proteins); EBP50 = Ezrin (show EZR Proteins)-Radixin (show RDX Proteins)-Mosein binding phosphoprotein 50)
NHERF1/EBP50 encompasses the regulation of several major signaling pathways engaged in cancer, including the receptor tyrosine kinases PDGFR (show PDGFRB Proteins) and EGFR (show EGFR Proteins), PI3K (show PIK3CA Proteins)/PTEN/AKT (show AKT1 Proteins) and Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) pathways.
Data demonstrated that EBP50 overexpression inhibited the adhesion and migration of breast and cervical cancer cell lines and suppressed MMP-2 (show MMP2 Proteins) activity in these cells; while its knockdown promoted cell adhesion and migration, and enhanced the activity of MMP-2 (show MMP2 Proteins).This study reveals the anti-metastatic effect and a new mechanism of EBP50 action in breast and cervical cancer cells.
Data provide evidence for an important role of NHERF1 in the epithelial-mesenchymal transition of non-small-cell lung cancer cells, as well as migration.
This interaction is promoted by EPAC1 (show RAPGEF3 Proteins) activation, triggering its translocation to the plasma membrane and binding to NHERF1. Our findings identify a new CFTR (show CFTR Proteins)-interacting protein and demonstrate that cAMP activates CFTR (show CFTR Proteins) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1 (show RAPGEF3 Proteins).
we show here that NHERF1 loss from the PM is oncogenic in vivo through its influence on Wnt (show WNT2 Proteins)-APC (show APC Proteins)-beta-catenin (show CTNNB1 Proteins) and Hippo-YAP (show YAP1 Proteins) pathways.
Along with several single loci, the epistatic QTLs, SLC9A3R1 and NOS2 control for total number of piglets born and number of piglets born alive in a F(2) Iberian by Meishan intercross.
Results strongly support an important role for NHERF1 (show SLC9A3R2 Proteins) in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia.
our data identify EBP50 as a previously unidentified regulator of Nox1 (show NOX1 Proteins) and support that it promotes Nox1 (show NOX1 Proteins) activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS (show ROS1 Proteins), hypertrophy, and vasoconstriction and has implications for ROS (show ROS1 Proteins)-mediated physiological and pathophysiological processes.
The results provide evidence that NHERF1 (show SLC9A3R2 Proteins) mediates K(+) current activity through acceleration of the surface expression of ROMK1 (show KCNJ1 Proteins) K(+) channels in M-1 cells.
The NHERF1 (show SLC9A3R2 Proteins) is as putative molecular organizer of signal transduction in vomeronasal neurons.
we show here that NHERF1 (show SLC9A3R2 Proteins) loss from the PM is oncogenic in vivo through its influence on Wnt (show WNT2 Proteins)-APC (show APC Proteins)-beta-catenin (show CTNNB1 Proteins) and Hippo-YAP (show YAP1 Proteins) pathways.
NHERF1 (show SLC9A3R2 Proteins) mediates ANG II (show AGT Proteins)-induced activation of renal NHE3 (show SLC9A3 Proteins), which requires coordination between IRBIT (show AHCYL1 Proteins) and the NHERF1 (show SLC9A3R2 Proteins) PDZ1 domain in binding and transporting NHE3 (show SLC9A3 Proteins)
These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes.
the activation of PTEN and NHERF-1 may impede the evolution of macrophages beyond the M1 into M2 phenotype in tumor microenvironment.
Data show that interaction of the inducible nitric oxide synthase (iNOS (show NOS2 Proteins)) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 (show PDZK1 Proteins) protein CAP70 (show PDZK1 Proteins) resulted greater nitric oxide (NO) synthesis.
The expression of EBP50 was not significantly different in the pseudopregnant uterus and decreased in the uteri subjected to activation of delayed implantation.
study found mainly nuclear localization of EBP50 in interphase cells, and its redistribution to cytoplasm during mitosis parallel with its phosphorylation; PP2A (show PPP2R2B Proteins) was identified as an interacting protein of EBP50 during pro-, prometa-, meta-, ana (show BTG3 Proteins)-, telophase, and early cytokinesis
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
, Na+/H+ exchange regulatory co-factor
, ezrin-radixin-moesin binding phosphoprotein-50
, ezrin-radixin-moesin-binding phosphoprotein 50
, regulatory cofactor of Na(+)/H(+) exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
, solute carrier family 9 isoform A3 regulatory factor 1
, sodium-hydrogen exchanger regulatory factor 1
, solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
, solute carrier family 9 sodium/hydrogen exchanger member 3 regulator 1
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
, ERM-binding phosphoprotein
, Na(+)/H(+) exchange regulatory cofactor NHE-RF
, solute carrier family 9 isoform 3 regulatory factor 1
, NHE3 kinase A regulatory protein 1
, SLC9A3 regulator 1 S homeolog
, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 S homeolog