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|Antigen||Bone Morphogenetic Protein 2 (BMP2) Antibodies|
|Epitope||AA 283-312, C-Term Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This BMP2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
|14 references available|
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Product Details anti-BMP2 AntibodyTarget Details BMP2 Application Details Handling References for anti-BMP2 antibody (ABIN3043489) Images
|Purpose||Rabbit IgG polyclonal antibody for Bone morphogenetic protein 2(BMP2) detection. Tested with WB, IHC-P, ELISA in Human,Rat.|
|Sequence||QAKHKQRKRL KSSCKRHPLY VDFSDVGWND|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Bone morphogenetic protein 2(BMP2) detection. Tested with WB, IHC-P, ELISA in Human,Rat.
Gene Name: bone morphogenetic protein 2
Protein Name: Bone morphogenetic protein 2
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human BMP-2 (283-312aa QAKHKQRKRLKSSCKRHPLYVDFSDVGWND), identical to the related mouse and rat sequences.|
Target Details BMP2Product Details anti-BMP2 Antibody Application Details Handling References for anti-BMP2 antibody (ABIN3043489) Images back to top
|Alternative Name||BMP2 (BMP2 Antibody Abstract)|
BMP2 is also known as Bone morphogenetic protein 2 or BMP2A. It is mapped to 20p12. The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. BMP-2, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. Also, it is involved in cardiac cell differentiation and epithelial to mesenchymal transition. In addition, BMP2A has been suggested as a reasonable candidate for the human condition fibrodysplasia (myositis) ossificans progressiva, on the basis of observations in a Drosophila model.
Synonyms: BDA2 antibody|BMP-2 antibody|BMP-2A antibody|Bmp2 antibody|BMP2_HUMAN antibody|BMP2A antibody|Bone morphogenetic protein 2 antibody| Bone morphogenetic protein 2A antibody
|Pathways||Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-BMP2 Antibody Target Details BMP2 Handling References for anti-BMP2 antibody (ABIN3043489) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-BMP2 Antibody Target Details BMP2 Application Details References for anti-BMP2 antibody (ABIN3043489) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-BMP2 antibody (ABIN3043489)Product Details anti-BMP2 Antibody Target Details BMP2 Application Details Handling Images back to top
|Product cited in:||
Liu, Chen, Zeng, Cui, Ning, Wang, Belguise, Wang, Qian, Lu, Yi: "Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling." in: Experimental cell research, Vol. 336, Issue 1, pp. 109-18, 2015
Wang, Xue, Zhao, Liu, Ma, Ma: "Form-deprivation myopia induces decreased expression of bone morphogenetic protein-2, 5 in guinea pig sclera." in: International journal of ophthalmology, Vol. 8, Issue 1, pp. 39-45, 2015
Chai, Guo, Wang, Gao, Liu, Fu, Guan, Tan, Yang: "In vitro and in vivo evaluations on osteogenesis and biodegradability of a β-tricalcium phosphate coated magnesium alloy." in: Journal of biomedical materials research. Part A, Vol. 100, Issue 2, pp. 293-304, 2014
Guo, Zeng, Yan, Shen, Liu, Li, Zhang, Wu, Guan, Huang: "Proliferative effect and osteoinductive potential of extracellular matrix coated on cell culture plates." in: SpringerPlus, Vol. 2, Issue 1, pp. 303, 2014
Sun, Sun, Tian, Xu, Zhou, Xi, Yan, Wang: "A comparison of osteocyte bioactivity in fine particulate bone powder grafts vs larger bone grafts in a rat bone repair model." in: Acta histochemica, Vol. 116, Issue 6, pp. 1015-21, 2014
Zhong, Liu, Dai, Zhou, Fu: "Sodium thiosulfate protects human aortic smooth muscle cells from osteoblastic transdifferentiation via high-level phosphate." in: The Kaohsiung journal of medical sciences, Vol. 29, Issue 11, pp. 587-93, 2013
Li, Chen, Wu, Jiang, Ge, Gao, Zhang, Wu: "Enhancement of the osseointegration of a polyethylene terephthalate artificial ligament graft in a bone tunnel using 58S bioglass." in: International orthopaedics, Vol. 36, Issue 1, pp. 191-7, 2012
Wang, Liu, Dang, Ma, Zhang, Wang: "The effect of core decompression on local expression of BMP-2, PPAR-γ and bone regeneration in the steroid-induced femoral head osteonecrosis." in: BMC musculoskeletal disorders, Vol. 13, pp. 142, 2012
Chen, Kong, Wan, Xiao, Li, Wang, Lin, Wang: "Effects of huogu I formula (I) on correlated factors of bone regeneration in chickens with steroid-induced necrosis of femoral head." in: Chinese journal of integrative medicine, Vol. 18, Issue 5, pp. 378-84, 2012
Yao, Wang, Wang, Wang, Zhang, Liu: "Synergistic enhancement of new bone formation by recombinant human bone morphogenetic protein-2 and osteoprotegerin in trans-sutural distraction osteogenesis: a pilot study in dogs." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 69, Issue 11, pp. e446-55, 2011
Han, Li, Guan: "Ectopic osteogenesis of hBMP-2 gene-transduced human bone mesenchymal stem cells/BCB." in: Connective tissue research, Vol. 51, Issue 4, pp. 274-81, 2010
Liu, Zhong, Liang, Fu, Luo, Zhou, Gou, Huang: "Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfα-1 pathway." in: Journal of Zhejiang University. Science. B, Vol. 11, Issue 12, pp. 905-11, 2010
Ma, Ma, Guo, Zhang: "Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients." in: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 85, 2010
Tian, Sun, Zhang, Gao, Fu, Yang: "Construction and expression of a bicistronic vector containing human bone morphogenetic protein 2 and vascular endothelial growth factor-165 genes in vitro." in: Chinese medical journal, Vol. 122, Issue 4, pp. 471-3, 2009
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