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Human FCGRT Protein expressed in Wheat germ - ABIN1353903
Deissler, Lang, Lang: Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor. in Experimental eye research 2015
Human FCGRT Protein expressed in HEK-293 Cells - ABIN2720989
Fan, Neubert: Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS. in Analytical chemistry 2016
Domains distal from the Fc could contribute to FcRn binding of IgG and alter antibody pharmacokinetics.
As expected, recombinant factor IX (without albumin fusion) and an FcRn interaction-defective albumin variant localized to the lysosomal compartments of both FcRn-expressing and nonexpressing cells. These results indicate that FcRn-mediated recycling via the albumin moiety is a mechanism for the half-life extension of rIX-FP observed in clinical studies.
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181.
we have demonstrated that loss of FcRn expression promotes tumor cell growth and proliferation. Our data support a model in which FcRn-mediated recycling of albumin reduces amino acid availability to fuel metabolic pathways.
An arginine-to-histidine replacement at residue 435 in the binding domain of IgG3 to FcRn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is associated with reduced risk of clinical malaria during infancy.
these findings establish a novel mechanism of humoral protection in the eye involving FcRn and may facilitate vaccine and therapeutic development for other ocular surface diseases
Data suggest that, unlike albumin with low FcRn-binding affinity, albumin with high FcRn-binding affinity (due to genetic variation/genetic engineering) is directed less to lysosomes and more to endosomes, suggestive of FcRn-directed albumin salvage from lysosomal degradation. (FcRn = neonatal Fc receptor)
the localization of FcRn alpha-chain in fixed nasal tissue, was studied.
FcRn is involved in transport of aflibercept through REC in vitro.
this study shows that FcRn may be associated with the transport and metabolism of IgG in thyrocytes and that transport is independent of IgG type, and that FcRn may be involved in Hashimoto's thyroiditis pathogenesis
This review summarizes the main findings on Fc Receptor neonatal biology, function and distribution throughout different tissues.
The results suggest that regardless of hyperglycemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.
Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.
analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1, Sp2, Sp3, c-Fos, c-Jun, YY1, and C/EBPbeta or C/EBPdelta) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression
These data indicate that human FcRn facilitates the transepithelial transport of IgE in the form of IgG anti-IgE/IgE ICs.
none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT, showed an association with the response to TNFi in patients with rheumatoid arthritis
Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris.
FcRn binding activity of a large set of Fc-fusion samples after thermal stress, was investigated.
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
These results suggest that hFcRn Tgm are a valuable and useful tool for pharmacokinetic screening of mAbs and Fc-fusion proteins in the preclinical stage.
Transmissible gastroenteritis virus infection up-regulates FcRn expression via activation of NF-kappaB signaling.NF-kappaB has 4 binding sites in the FcRn promoter.
The transport of IgGs in the mammary gland, by FcRn, was investigated.
The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
The main function of hepatic FcRn is to direct albumin into the circulation, thereby also increasing hepatocyte sensitivity to toxicity.
Preproinsulin fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.
Characterization and screening of IgG binding to the neonatal Fc receptor.
Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance
Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.
Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis.
AMG 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.
an increase in lymphoid follicles and Helicobacter bacterial load in knock-out mice
Data show that FcRn traps antigen and protects it from degradation within an acidic loading compartment in association with the rapid recruitment of key components of the phagosome-to-cytosol cross-presentation machinery.
Findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs.
These studies demonstrate that FcRn-mediated transport is a mechanism by which IgG can act locally in the female genital tract in immune surveillance and in host defense against sexually transmitted diseases.
Fetal, but not maternal, FcRn is required for induction of Fetal and neonatal immune thrombocytopenia.
No binding of albumin was observed at physiological pH to neonatal Fc receptor. At acidic pH, a 100-fold difference in binding affinity was observed.
Mouse FcRn is promiscuous in its antibody binding specificity, interacting with IgG from human, mouse, rabbit, guinea pig, bovine, sheep and rat.
Direct evidence is provided that FcRn is responsible for both perinatal IgG transport and IgG homeostatic function.
FcRn promotes humorally mediated autoimmune disease.
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
FcRn alpha chain
, IgG Fc fragment receptor transporter alpha chain
, IgG receptor FcRn large subunit p51
, immunoglobulin receptor, intestinal, heavy chain
, major histocompatibility complex class I-like Fc receptor
, neonatal Fc receptor
, neonatal Fc-receptor for Ig
, IgG transcytosis and recycling receptor
, MHC class I-related Fc gamma receptor
, igG receptor FcRn large subunit p51
, neonatal Fc receptor FcRn
, Fc receptor
, Fc fragment immunoglobulin G receptor
, Fc receptor, IgG, alpha chain transporter
, igG Fc fragment receptor transporter alpha chain