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Human Forkhead Box F1 (FOXF1) interaction partners

1. Data suggest that that forkhead box F1 (FOXF1) might promote angiogenesis by directly binding to the vascular endothelial growth factor A (VEGFA) promoter to induce its expression.

2. These findings indicated that miR-152-3p regulates cell proliferation, invasion and extracellular matrix expression through targeting FOXF1 in keloid fibroblasts, suggesting that miR-152-3p is a novel and promising molecular target for keloid treatment.

3. our data indicate that FOXF1 represents not only a novel diagnostic biomarker, but also a potential novel therapeutic target in GIST.

4. FOXF1 rs3950627 was significantly associated with survival in gastric cancer patients from two populations; Japan and California.

5. Mutations in SFTPC, NKX2.1, and FOXF1 were identified among Japanese infants and children with childhood interstitial lung disease, whereas ABCA3 mutations were rare.

6. FOXF1 plays a critical role in colorectal cancer metastasis by inducing epithelial-mesenchymal transition via transcriptional activation of SNAI1.High expression and nuclear location of FOXF1 were significantly associated with the aggressive characteristics and poorer survival of colorectal cancer patients.

7. a novel cascade mediated by AP-1 and FOXF1 that regulates oncogene-induced senescence, is reported.

8. circNASP contributes to malignant behaviors of osteosarcoma cells by miR-1253/FOXF1 pathway.

9. the varients of FOXP1 and FOXF1 genes are functionally associated with oesophageal adenocarcinoma in Chinese population.

10. gene polymorphism is associated with increased colorectal cancer risk in the Han Chinese population

11. we describe monozygotic twins and one full-term newborn with ACD and gastrointestinal malformations caused by de novo mutations of FOXF1 on the maternal-inherited alleles.

12. reported the first familial case of ACDMVP as a result of maternal somatic mosaic FOXF! mutation, which provided additional evidence for this novel imprinting disorder

13. FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling

14. the R139Q substitution in FOXF1 causes infantile hypertrophic pyloric stenosis in a family and implies a novel pathological pathway for the condition

15. Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development.

16. FOXF1 mutations may have an extremely variable phenotype, possibly as a result of somatic mosaicism and complex gene regulation.

17. There were decreased levels of Gsa, FOXF1, CREB1, and phosphorylated CREB1 proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls.

18. Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1-mediated Wnt5a/beta-Catenin signaling pathway, and suppresses GC cell apoptosis through MYOD1-mediated Caspase-3 signaling pathway.

19. Results show that FoxF1 increases invasiveness of breast cancer cells by upregulating LOX.

20. we provide supportive evidence that genetic variants at FOXP1, BARX1, and FOXF1 confer risk for the development of EAC.

Mouse (Murine) Forkhead Box F1 (FOXF1) interaction partners

1. FOXF1 deletion increases myofibroblast invasion and collagen secretion and promotes a switch from N-cadherin (CDH2) to Cadherin-11 (CDH11), which is a critical step in the acquisition of the pro-fibrotic phenotype. FOXF1 directly binds to Cdh2 and Cdh11 promoters and differentially regulates transcription of these genes.

2. Thus FOXF1 stimulates lung regeneration following partial pneumonectomy via direct transcriptional regulation of genes critical for extracellular matrix remodeling and cell cycle progression.

3. It is concluded that during early pseudoglandular stage of lung development Ptch1 patterns Fgf10 and regulates Foxf1 expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function.

4. FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling

5. Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function.

6. The Gli increased the activity of one of these long-range enhancers, which was specific to distal blood vessel, suggesting that Shh regulates Foxf1 transcription in pulmonary distal blood vessel formation.

7. Data indicate that forkhead box F1 (Foxf1) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1).

8. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association

9. novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression

10. findings suggest that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC-specific delivery of therapeutic RNA

11. Our findings implicate Foxf genes(Foxf1a and Foxf2 ) in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog signaling and Tbx5

12. Data indicate FOXF1 transcription factor is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling.

13. Endodermal Shh and mesenchymal Foxf1 genes expression were preserved around the hindgut cystic malformation.

14. Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs).

15. Observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors.

16. Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development

17. Foxf1 +/- mice exhibited abnormal liver repair, diminished activation of hepatic stellate cells, and increased pericentral hepatic apoptosis following CCl(4) injury.

18. Foxf1 haploinsufficiency disrupted pulmonary expression of genes in the Notch-2-signaling pathway and resulted in abnormal development of lung microvasculature.

19. The developmental expression of forkhead box f1 (Foxf1) in mice is reported.

20. Foxf proteins are mesenchymal factors that control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling.

Xenopus laevis Forkhead Box F1 (FOXF1) interaction partners

1. Results provide support for the function of FoxF1 in the development of visceral mesoderm and the organogenesis of the gut.