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Full name:: Syntaxin Binding Protein 2 Proteins (STXBP2)

On www.antibodies-online.com are 5 Syntaxin Binding Protein 2 (STXBP2) Proteins from 3 different suppliers available. Additionally we are shipping STXBP2 Antibodies (56) and and many more products for this protein. A total of 64 STXBP2 products are currently listed.

Synonyms:: C79054, FHL5, Hunc18b, MUNC-18-2, Munc-18b, MUNC18-2, Munc18b, muSec1, pp10122, Sxtbp2, Sxtp2, Unc18-2, Unc18b, zgc:85807

list all proteins	Gene Name	GeneID	UniProt
	STXBP2	6813	Q15833
	STXBP2	20911	Q64324
	STXBP2	81804	Q62753
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Human Syntaxin Binding Protein 2 (STXBP2) interaction partners

Neonatal platelets exhibit low levels of the Stx11 (show STX11 Proteins)-Munc18b complex (essential component of the SNARE (show NAPA Proteins) machinery) and of beta1-tubulin (show TUBB Proteins). These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion.
Among these nine polymorphisms, rs188212047 [G/T (L212F)] of STXBP2 was significantly (dominant model; P = 4.84 x 10-8; odds ratio, 2.94) associated with myocardial infarction. STXBP2 may thus be a novel susceptibility locus for myocardial infarction in Japanese.
STXBP2 Gene Polymorphism is associated with Hemophagocytic Lymphohistocytosis.
Mutation in STXBP2 gene is associated with hemophagocytic lymphohistiocytosis.
Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs (show FBN1 Proteins) in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets.
two novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious.
red blood cells express Munc18-2 and that erythroid cells from patients with FHL-5 exhibit intrinsic defects caused by STXBP2/Munc18-2 mutations.
Munc18-2(R65Q) and Munc18-2(R65W) retain the ability to interact with and stabilize STX11 (show STX11 Proteins). However, presence of Munc18-2(R65Q/W) in patient-derived lymphocytes and forced expression in control CTLs and NK cells diminishes degranulation and cytotoxicity.
Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D (show UNC13D Proteins) or STXBP2.
Munc18-2 binds the N-terminal peptide of Stx11 (show STX11 Proteins) with a ~20-fold higher affinity than Stx3 (show STX3 Proteins), suggesting a potential role in selective binding.

Mouse (Murine) Syntaxin Binding Protein 2 (STXBP2) interaction partners

SNARE (show VTI1B Proteins) zippering requires activation by SNARE (show VTI1B Proteins)-like peptides in Sec1/Munc18 proteins
Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and mast cell.
Munc18-1 (show STXBP1 Proteins) and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin (show INS Proteins) exocytotic process differently as a consequence of the actual [Ca(2 (show CA2 Proteins)+)](i).

STXBP2 Protein Profile

Protein Summary

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with STXBP2

syntaxin binding protein 2 (stxbp2)
syntaxin binding protein 2 (STXBP2)
syntaxin binding protein 2 (Stxbp2)

C79054 protein
FHL5 protein
Hunc18b protein
MUNC-18-2 protein
Munc-18b protein
MUNC18-2 protein
Munc18b protein
muSec1 protein
pp10122 protein
Sxtbp2 protein
Sxtp2 protein
Unc18-2 protein
Unc18b protein
zgc:85807 protein

Protein level used designations for STXBP2

syntaxin-binding protein 2 , protein unc-18 homolog B , unc-18B , munc18-2 , protein unc-18 homolog 2 , syntaxin binding protein Munc18-2 , unc-18 homolog 2 , unc18-2 , Sec1 homolog

GENE ID	SPECIES
406578	Danio rerio
515618	Bos taurus
100171766	Pongo abelii
6813	Homo sapiens
20911	Mus musculus
81804	Rattus norvegicus
403880	Canis lupus familiaris
100525152	Sus scrofa

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