TXK tyrosine Kinase ELISA Kit

1 product by 1 suppliers: RayBiotech
View Product
96 tests
Recommendations are based on data provided indicating:
  • ELISA Kit Sensitivity
    The recommended ELISA Kit will likely detect the antigen better in the approved sample types than the available alternatives.
  • ELISA Kit Specificity
    The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives.
  • Experiment Reproducibility
    The results will be likely more reproducible, with high inter- or intra-assay CV and Recovery (for values within the std curve) than the available alternatives.
  • ELISA Kit Robustness
    The recommended assay will likely function better with approved sample types, and will not suffer from undue matrix interference than the available alternatives.
Picking recommended ELISA Kits will save you time - yet all 1 products covered by our Money Back Guarantee!

TXK Antigen Profile

Antigen Summary

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Alternative names and synonyms associated with TXK

  • TXK tyrosine kinase (TXK) ELISA Kit
  • TXK tyrosine kinase (Txk) ELISA Kit
  • tyrosine-protein kinase TXK (LOC100544958) ELISA Kit
  • PTK4 ELISA Kit
  • A130089B16Rik ELISA Kit
  • Btkl ELISA Kit
  • Rlk ELISA Kit

Protein level used designations for TXK

PTK4 protein tyrosine kinase 4 , protein-tyrosine kinase 4 , resting lymphocyte kinase , tyrosine kinase , tyrosine-protein kinase TXK , PTK-RL-18 , TXK tyrosine kinase , tyrosine-protein kinase TXK-like , LOW QUALITY PROTEIN: tyrosine-protein kinase TXK

7294 Homo sapiens
22165 Mus musculus
305311 Rattus norvegicus
444993 Sus scrofa
461344 Pan troglodytes
482139 Canis lupus familiaris
504782 Bos taurus
705104 Macaca mulatta
770387 Gallus gallus
100019276 Monodelphis domestica
100054343 Equus caballus
100341671 Oryctolagus cuniculus
100397226 Callithrix jacchus
100455862 Pongo abelii
100464564 Ailuropoda melanoleuca
100544958 Meleagris gallopavo
100598060 Nomascus leucogenys
100722451 Cavia porcellus
Did you look for something else?