Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

TXK Products

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured TXK Categories

TXK Antibodies

High quality antibodies with extensive validation data.

TXK ELISA Kits

Reliable ELISA kits for a wide range of species.

TXK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TXK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7174076
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN392114
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (3)
Cat. No. ABIN570663
Quantity 100 μg
Datasheet Datasheet

Recommended TXK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971009
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886333
Quantity 96 tests
Datasheet Datasheet

Recommended TXK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324214
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Insect Cells
Validations
Cat. No. ABIN5509229
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509188
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our TXK products

Suzuki, Nara, Suzuki: "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease." in: Clinical medicine & research, Vol. 4, Issue 2, pp. 147-51, (2006) (PubMed).

Takeba, Nagafuchi, Takeno, Kashiwakura, Suzuki: "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2365-70, (2002) (PubMed).

Synonyms and alternative names related to TXK

TXK tyrosine kinase (TXK), TXK tyrosine kinase (Txk), tyrosine-protein kinase TXK (LOC100544958), A130089B16Rik, BTKL, Btkl, PSCTK5, PTK4, RLK, Rlk, TKL

Protein level used designations for TXK

  • PTK4 protein tyrosine kinase 4
  • protein-tyrosine kinase 4
  • resting lymphocyte kinase
  • tyrosine kinase
  • tyrosine-protein kinase TXK
  • PTK-RL-18
  • TXK tyrosine kinase
  • tyrosine-protein kinase TXK-like
  • LOW QUALITY PROTEIN: tyrosine-protein kinase TXK
You are here:
Support