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anti-Mouse (Murine) DDIT3 Antibodies:
anti-Rat (Rattus) DDIT3 Antibodies:
anti-Human DDIT3 Antibodies:
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Human Monoclonal DDIT3 Primary Antibody for GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 17 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. in Investigative ophthalmology & visual science 2015
Show all 8 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 Pubmed References
Mouse (Murine) Monoclonal DDIT3 Primary Antibody for IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. in The EMBO journal 1998
Show all 2 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Human Polyclonal DDIT3 Primary Antibody for ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
Human Monoclonal DDIT3 Primary Antibody for ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP activity and inhibition of the protective activity of p21 (show D4S234E Antibodies).
Activation of the ER stress execution proteins, PERK (show EIF2AK3 Antibodies) and CHOP10, was evaluated to determine whether this process was involved in 15d-PMJ2 cell death. 15d-PMJ2 increased the phosphorylation of PERK (show EIF2AK3 Antibodies) and expression of CHOP10 in tumorigenic but not nontumorigenic cells
Chop was found to exacerbate allergic airway inflammation by enhancing M2 programming in macrophages
Our findings support that CHOP may be an important signaling molecule in the progression of chronic kidney disease
GPR4 (show GPR4 Antibodies) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
CHOP deficiency prevents HFD-induced insulin (show INS Antibodies) resistance.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (show LEP Antibodies) and IGF1 (show IGF1 Antibodies).
a significant protein-protein interaction between GR and CHOP, (GR-CHOP heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
The study shows that FXR (show NR1H4 Antibodies)/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
Ddit3 suppresses the differentiation of ATDC5 cells
siRNA silencing of CHOP significantly reduced cyproterone acetate-induced DR5 (show TNFRSF10B Antibodies) up-regulation and TRAIL sensitivity in prostate cancer cells. Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer
asthmatic patients exhibited aberrant Chop expression along with endoplasmic reticulum stress
CHOP negatively regulates Polo-like kinase 2 (show PLK2 Antibodies) expression via recruiting C/EBPalpha (show CEBPA Antibodies) to the upstream-promoter in human osteosarcoma cell line during ER stress
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
GRP78 (show HSPA5 Antibodies) inhibition enhances ATF4 (show ATF4 Antibodies)-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma cells.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (show MAPK8 Antibodies), AP-1 (show FOSB Antibodies), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (show ELANE Antibodies) in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 Antibodies) and CHOP is reported.
CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3