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Human Polyclonal DRD5 Primary Antibody for IF (p), IHC (p) - ABIN733868
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
Mouse (Murine) Monoclonal DRD5 Primary Antibody for ICC, IF - ABIN258727
Luedtke, Griffin, Conroy, Jin, Pinto, Sesack: Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes. in Journal of neuroimmunology 1999
Dopamine D5 receptor may play an important role in the preservation of normal heart function by inhibiting the production of reactive oxygen species, via inhibition of NADPH oxidase, Nrf2 degradation, and ERK1/2/JNK pathways.
The C allele of DRD5 rs6283 SNP was associated with decreased risk of awake bruxism (p = 0.01).
DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth.
Meta-analysis of data from six sites of the International Multicentre persistent ADHD CollaboraTion tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts, found evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.
Study investigated the contribution of DRD5 gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD): 19 exonic variants were monomorphic in the Indo-Caucasoid individuals. rs6283 "C" and rs113828117 "A" exhibited significant higher occurrence in families with ADHD probands. Early and late onset groups exhibited significantly different genotypic frequencies.
This study reveled that DRD5 are up regulation in CD4+ T effector and regulatory cells in patient with multiple sclerosis.
DRD5 gene expression reduction in breast cancer patients after spiritual intervention
Conserved residues in intracellular loop 1 and transmembrane region 2 of DRD1 and DRD5 are essential in ligand binding and signal transduction.
D1R and D5R colocalize in renal proximal tubule cells and physically interact in second messenger coupling pathways and heterologous receptor interaction between the two receptors.
This study shown DRD5 to be the risk factor for attention deficit/hyperactivity disorder.
LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling.
We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level.
This study demonistrated that Lymphocyte DR D5 is reduced in MS and IFN-beta restores their expression and responsiveness.
Constitutive D5R signalling up-regulated expression of Na,K-ATPase-alpha2 and NHE-2, increasing glucose metabolism. Agonist treatment increased this and also upregulated NHE-3.
Our find-ings suggest that common genetic variations of DRD5 are likely to con-tribute to genetic susceptibility to paranoid schizophrenia in Han Chinese
Its signaling regulates human osteoclastogenesis. (review)
in this report, the specific amino acids in the cytoplasmic regions of D5 and D2 receptors involved in heteromer interactions were determined.
confirmed at protein level the previously reported increased expression of DRD5 and the variably aberrant expression of ADORA2A, in Lesch-Nyhan disease lymphocytes
SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
n T2 mice, the mRNA expression of Retn showed a moderate up-regulation (fold change=8.32; p=0.0019) in the adipose tissues. Iapp expression was also significantly up-regulated (fold change=9.78; p=0.012). Moreover, a 6.36-fold up-regulation for Drd5 was observed in the adipose tissues of T2 mice
Findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction.
Findings demonstrate the relevant contribution of dopamine receptor D5 (D5R) in memory and suggest a functional interaction of D5R with hippocampal glutamatergic pathways.
Data provides evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation
CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake
long-term memory consolidation depends on local D1/5 receptor signaling.
We suggest that the ability of the dopamine D5 receptor to negatively regulate the renal NADPH oxidase activity and AT1R function may have important implications in the pathogenesis of salt-sensitive blood pressure.
This study demonstrated that D5R stimulation contributes to an efficient CD4(+)T-cell-induced early ERK1/2 phosphorylation, and differentiation.
The dopamine D5 receptors are particularly important in regulating plasticity of the medial perforant path onto the dentate granule cells.
These results suggest that dentate gyrus D1Rs, but not D5Rs, contribute to the formation of distinct contextual representations of novel environments.
The renal D5R protein upregulation was not caused by increased transcription because renal mRNA expression of D5R was similar in D3(-/-) and D3(+/+) mice.
This study demonistrated that the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.
By contributing to CD4(+) T cell activation and differentiation to Th17 phenotype, D5R expressed on DCs is able to modulate the development of an autoimmune response in vivo.
We propose that ciliary DR5 has functional chemo- and mechano-sensory roles in endothelial cells.
There is a role of renal D(5) receptors in blood pressure homeostasis and the pathogenesis of hypertension in mice.
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.
Dopamine D5 receptor knockout mice were used to study the role of D5 dopamine receptors in the locomotor-discriminative effects of cocaine.
D1 and D5 receptors exert distinct actions on both activity-dependent synaptic plasticity and spontaneous motor activity. Accordingly, ablation of D1 receptors disrupted corticostriatal LTP, whereas pharmacological blockade of D5 receptors prevented LTD
these results confirm and extend the role of the d5 receptor in the modulation of hippocampal acetylcholine release and provide evidence for long-term alteration of hippocampal cholinergic neurotransmission
There were significant differences in the allelic frequencies among Bos taurus and Bos indicus breeds of different temperament for the DRD1, DRD4, and DRD5 markers.
these data provide evidence that functional D1/D5 receptors are expressed in the internal globus pallidus and the substantia nigra pars reticulata in both normal and parkinsonian states in monkeys
In the basolateral amygdala, the D1R subtypes colocalize in dendritic spines and terminals, with D(5) predominant in terminals. There were similarities between the primates and rats, such as more prominent D(5) localization to presynaptic structures.
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.
dopamine receptor D5
, D(1B) dopamine receptor-like
, D(1B) dopamine receptor
, D1beta dopamine receptor
, d(5) dopamine receptor
, dopamine D5 receptor
, dopamine receptor D1B
, dopamine receptor 5
, D(5) dopamine receptor
, D1b dopamine receptor
, D5 dopamine receptor
, dopamine D1B receptor