anti-Human Sepiapterin Reductase antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Sepiapterin Reductase Antibody (supplied by: Log in to see )

Antigen
Sepiapterin Reductase (SPR) Antibodies
  • SDR38C1
  • AA409688
  • ENSMUSG00000071345
  • Gm10328
  • CG12117
  • Dmel\\CG12117
  • SR
  • sptr
  • xspr
  • DDBDRAFT_0188686
  • DDBDRAFT_0191275
  • DDB_0188686
  • DDB_0191275
  • sepiapterin reductase
  • Sepiapterin reductase
  • sepiapterin reductase L homeolog
  • SPR
  • Spr
  • Sptr
  • spr.L
  • sprE
  • CpipJ_CPIJ000511
  • sr
  • spr
Reactivity
Human, Mouse (Murine), Rat (Rattus)
99
42
28
9
2
2
2
Host
Rabbit
67
33
Clonality
Polyclonal
Conjugate
Alexa Fluor 594
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
84
37
24
19
18
12
9
8
8
5
1
1
1
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Catalog No. ABIN2806639
$ 405.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1411193 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1393302 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1411191 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1393301 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1393300 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1393299 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1411192 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1411194 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal 0
1 ABIN1393304 IF (p) FITC Rabbit IgG Log in to see Polyclonal 0
1 ABIN1387925 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5010957 IF (p) Alexa Fluor 680 Rabbit IgG Log in to see Polyclonal 0
1 ABIN5010958 IF (p) Alexa Fluor 750 Rabbit IgG Log in to see Polyclonal 0

General

Antigen Sepiapterin Reductase (SPR) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(99), (42), (28), (9), (2), (2), (2)
Host Rabbit
(67), (33)
Clonality
Polyclonal
Conjugate Alexa Fluor 594
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(84), (37), (24), (19), (18), (12), (9), (8), (8), (5), (1), (1), (1)
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Product details

Target Details Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Sepiapterin reductase
Isotype IgG

Target Details

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Antigen
Alternative Name SPR/ Sepiapterin Reductase (SPR Antibody Abstract)
Background

SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.

Synonyms: SDR38C1, Sepiapterin reductase 7,8 dihydrobiopterin:NADP+ oxidoreductase, Sepiapterin reductase, Short chain dehydrogenase/reductase family 38C, member 1, SPR, SPRE_HUMAN.

Pathways Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration

Application Details

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Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months