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molecular substrate of a chloride channel (show CLCA1 Antibodies) previously detected in the mouse thick ascending limb
the major component of Cl(-) transport sensitive to NPPB (show BNP Antibodies) or pH is mediated by CLC-K1 in the tAL (show TALDO1 Antibodies).
Gene expression profiling in the collecting tubules of aquaporin-1 (show AQP1 Antibodies) and CLC (show CLC Antibodies)-Nk1 (show HGF Antibodies) knockout mice.
induction of SGK1 (show SGK1 Antibodies), CLC-K1 and barttin (show BSND Antibodies) by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro
Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk.
R8W and G47R, two naturally occurring barttin (show BSND Antibodies) mutations identified in patients with Bartter syndrome type IV, reduce barttin (show BSND Antibodies) palmitoylation and CLC-K (show CLCNKB Antibodies)/barttin (show BSND Antibodies) channel activity.
HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka (show CLCNKB Antibodies)/barttin (show BSND Antibodies) and CLC-Kb (show CLCNKB Antibodies)/barttin (show BSND Antibodies) channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved
following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype
The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 (show HSPB7 Antibodies) gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis.
Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K (show CLCNKB Antibodies) channels.
Combined impairment of ClC-Ka (show CLCNKB Antibodies) and ClC-Kb (show CLCNKB Antibodies) results in phenotype that mimics neonatal Barrter's syndrome with deafness
Barttin (show BSND Antibodies) modulates trafficking and function of ClC-K1 and ClC-Kb (show CLCNKB Antibodies) channels
CLCNKA genetic variants may have roles in salt-sensitive hypertension
The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface.
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
chloride channel Ka
, chloride channel protein ClC-Ka-like
, chloride channel K1
, chloride channel protein ClC-Ka
, putative basolateral cTAL chloride channel ClC-Ka
, chloride channel, kidney, A
, Chloride channel protein ClC-Kb
, chloride channel Kb