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mRNA Expression of Raldh3 during zebrafish early development.
Data show that retinoic acid receptor (show RARA Proteins) responder 1 (RARRES1 (show RARRES1 Proteins)) expression is subtype-dependent and regulated by DNA methylation (show HELLS Proteins) and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3).
ALDH1A3 is a poor prognostic factor for patients with intrahepatic cholangiocarcinoma who underwent hepatectomy and in those with advanced intrahepatic cholangiocarcinoma receiving chemotherapy.
high transcription activities of ALDH1A2 (show ALDH1A2 Proteins), ALDH1A3 and ALDH1L1 (show ALDH1L1 Proteins) predicted worsen overall survival in gastric cancer patients
Melanoma treatment with the novel irreversible isoform-specific ALDH1 (show ALDH1A1 Proteins) inhibitor [4-dimethylamino-4-methyl-pent (show PNMT Proteins)-2-ynthioic acid-S methylester] di-methyl-ampal-thio (show ACAA1 Proteins)-ester (DIMATE) or depletion of ALDH1A1 (show ALDH1A1 Proteins) and/or ALDH1A3, promoted the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in immunocompetent, immunosuppressed and patient-derived xenograft mouse models.
these findings ascribe a novel function for ALDH1A3 in an aggressive glioma stem cells phenotype via the up-regulation of tissue transglutaminase (show TGM2 Proteins)
our findings define a FOXD1 (show FOXD1 Proteins)-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors
we looked up our single center primary prostate cancer post-operative follow-up data and suggested that the high level ALDH1A3 expression could predict the poor progression-free survival in a 158-patient cohort. We concluded that ALDH1A3, localized in luminal layer in prostate epithelium, is highly expressed in prostate cancer
this report brings new information for the phenotype-genotype correlation of ALDH1A3 mutations and raises important questions, especially in terms of genetic counselling given to the patients and their families
ALDH1A3 was most relevant to extracellular matrix organization and cell adhesion biological process, and the ability of tumor invasion was suppressed after ALDH1A3 knockdown in vitro.
the prevalence of ALDH1A3(+)/CD44 (show CD44 Proteins)(+) tumor cells in breast cancer is significantly associated with worse prognostic factors and favors a poor prognosis
This study identifies Sam68 (show KHDRBS1 Proteins) as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.
Chromatin immunoprecipitation assay using RarB (show RARB Proteins) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 (show FOXN2 Proteins) in mice.
Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen (show GYS1 Proteins) trophoblast cells (junctional zone cells) via production of a local source of retinoic acid.
Raldh1 (show ALDH1A1 Proteins) and Raldh3 influence enteric nervous system structure and function and heterozygosity for Raldh2 (show ALDH1A2 Proteins) causes ENS defects
ALDH1A3 and ALDH2 (show ALDH2 Proteins) expression was detectable in ALDH (show ALDH3A1 Proteins)(very-br) and ALDH (show ALDH3A1 Proteins)(br) cells, unlike ALDH (show ALDH3A1 Proteins)(dim) cells, albeit at lower levels compared with ALDH1A1 (show ALDH1A1 Proteins) and ALDH1A2 (show ALDH1A1 Proteins).
regulation of fat depots through the concerted action of Aldh1 (show ALDH1A1 Proteins) enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma (show PPARG Proteins) in a depot-specific manner
Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates.
Raldh2 (show ALDH1A2 Proteins) and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development.
Three retinaldehyde dehydrogenases (RALDH1 (show ALDH1A1 Proteins), RALDH2 (show ALDH1A2 Proteins) and RALDH3), show differential expression patterns throughout later mouse organogenesis
RALDH3 is transiently expressed during early postnatal cortical development, suggesting an important role in cortical neuronal development.
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
aldehyde dehydrogenase 1A3
, aldehyde dehydrogenase 1 family, member A3
, aldehyde dehydrogenase family 1 subfamily A3-like
, aldehyde dehydrogenase family 1 member A3
, retinaldehyde dehydrogenase family 1 subfamily A3
, aldehyde dehydrogenase family 1 member A3-like
, acetaldehyde dehydrogenase 6
, aldehyde dehydrogenase 6
, retinaldehyde dehydrogenase 3
, aldehyde dehydrogenase family 1, subfamily A3
, aldehyde dehydrogenase-6