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|Antigen||EPH Receptor A5 (EPHA5) Antibodies|
|Conjugate||This EPH Receptor A5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-EPH Receptor A5 AntibodyTarget Details EPH Receptor A5 Application Details Handling Images
|Specificity||This antibody is specific to EPHA5.|
|Characteristics||Synonyms: Ephrin type-A receptor 5, Tyrosine-protein kinase receptor EHK-1, Eph homology kinase-1,Receptor protein-tyrosine kinase HEK7|
|Purification||Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||Purified His-tagged EPHA5 protein(Fragment).|
Target Details EPH Receptor A5Product Details anti-EPH Receptor A5 Antibody Application Details Handling Images back to top
|Alternative Name||EPHA5 (EPHA5 Antibody Abstract)|
|Background||EPHA5 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: EHK1, EPH homology kinase 1, Ephrin type-A receptor 5, HEK7, Receptor protein-tyrosine kinase HEK7, Tyrosine-protein kinase receptor EHK-1|
Application DetailsProduct Details anti-EPH Receptor A5 Antibody Target Details EPH Receptor A5 Handling Images back to top
|Application Notes||ELISA: 1/4,000. Western blotting: 1/2000. Immunohistochemistry.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-EPH Receptor A5 Antibody Target Details EPH Receptor A5 Application Details Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
ImagesProduct Details anti-EPH Receptor A5 Antibody Target Details EPH Receptor A5 Application Details Handling back to top