General
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Antigen
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EPH Receptor B2 (EPHB2) Antibodies
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Epitope
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pTyr469
Alternatives
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Reactivity
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Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Non-Human Primate, Xenopus laevis, Zebrafish (Danio rerio)
Alternatives
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Host
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Rabbit
Alternatives
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Clonality
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Conjugate
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This EPH Receptor B2 antibody is un-conjugated
Alternatives
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Application
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Western Blotting (WB)
Alternatives
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Supplier
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Log in to see
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Specificity
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Recognizes the EPHB2 protein phosphorylated at tyrosine 469
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Cross-Reactivity
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Human, Mouse (Murine), Cow (Bovine), Dog (Canine), Chicken, Non-Human Primate, Xenopus laevis, Zebrafish (Danio rerio)
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Purification
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Affinity Chromatography
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Immunogen
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Synthetic phospho-peptide corresponding to amino acid residues surrounding pTyr469 conjugated to KLH
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Isotype
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IgG
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Plasmids, Primers & others
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Antigen
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Alternative Name
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EPHB2 (EPHB2 Antibody Abstract)
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Background
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EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neuro-developmental processes such as boundary formation, axon guidance, vasculogenesis and cell migration. Activated EPHB2 regulates the activity of the non-receptor tyrosine kinase Abl (1). EPHB2 is overexpressed in a number of tumors, particularly glioblastoma. In fact, EPHB2 overexpression leads to increased glioma cell migration and invasion (2).
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Pathways
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RTK Signaling, Regulation of long-term Neuronal Synaptic Plasticity
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Restrictions
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For Research Use only
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Format
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Liquid
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Buffer
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100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
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Handling Advice
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For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Storage
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4 °C,-20 °C
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Storage Comment
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Store at 4 °C (add 0.1% NaN3) for several months, and at -20 °C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
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