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|Antigen||Fibroblast Growth Factor Receptor 4 (FGFR4) Antibodies|
|Conjugate||This FGFR4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
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Product Details anti-FGFR4 AntibodyTarget Details FGFR4 Application Details Handling References for anti-FGFR4 antibody (ABIN359860) Images
|Specificity||This antibody reacts to FGFR4.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with recombinant human FGFR4 protein.|
Target Details FGFR4Product Details anti-FGFR4 Antibody Application Details Handling References for anti-FGFR4 antibody (ABIN359860) Images back to top
|Alternative Name||CD334 / FGFR4 (FGFR4 Antibody Abstract)|
|Background||FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.Synonyms: FGFR-4, Fibroblast growth factor receptor 4, JTK2, TKF|
|Gene ID||2264, 9606|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding|
Application DetailsProduct Details anti-FGFR4 Antibody Target Details FGFR4 Handling References for anti-FGFR4 antibody (ABIN359860) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGFR4 Antibody Target Details FGFR4 Application Details References for anti-FGFR4 antibody (ABIN359860) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-FGFR4 antibody (ABIN359860)Product Details anti-FGFR4 Antibody Target Details FGFR4 Application Details Handling Images back to top
Jézéquel, Campion, Joalland, Millour, Dravet, Classe, Delecroix, Deporte, Fumoleau, Ricolleau: "G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis." in: British journal of cancer, Vol. 90, Issue 1, pp. 189-93, 2004
Qian, Sano, Asa, Yamada, Horiguchi, Tashiro, Li, Hirokawa, Kovacs, Ezzat: "Cytoplasmic expression of fibroblast growth factor receptor-4 in human pituitary adenomas: relation to tumor type, size, proliferation, and invasiveness." in: The Journal of clinical endocrinology and metabolism, Vol. 89, Issue 4, pp. 1904-11, 2004
Yu, Asa, Weigel, Ezzat: "Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19597-602, 2003
Becker, Nieters, Chang-Claude: "The fibroblast growth factor receptor gene Arg388 allele is not associated with early lymph node metastasis of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 12, Issue 6, pp. 582-3, 2003
Takenaka, Yasuno, Kishimoto: "Immunolocalization of fibroblast growth factor receptors in normal and wounded human skin." in: Archives of dermatological research, Vol. 294, Issue 7, pp. 331-8, 2002
ImagesProduct Details anti-FGFR4 Antibody Target Details FGFR4 Application Details Handling References for anti-FGFR4 antibody (ABIN359860) back to top