anti-Mouse (Murine) FGFR4 antibody for Flow Cytometry

Recommended FGFR4 Antibody (supplied by: Log in to see )

Antigen
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibodies
  • FGFR4
  • XFGFR-4
  • XFGFR-4a
  • cd334
  • fgfr-4
  • jtk2
  • tkf
  • xfgfr4
  • CD334
  • JTK2
  • TKF
  • Fgfr-4
  • etID309818.21
  • wu:fc13h10
  • zgc:111935
  • fgfr-4c
  • fgfr4
  • fibroblast growth factor receptor 4
  • fibroblast growth factor receptor 4 S homeolog
  • FGFR4
  • fgfr4
  • Fgfr4
  • fgfr4.S
Epitope
AA 40-90
18
16
15
10
10
9
6
6
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
207
59
49
3
3
Host
Rabbit
131
73
17
Clonality
Polyclonal
Conjugate
This FGFR4 antibody is conjugated to PE
9
8
6
5
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
166
105
63
40
34
29
13
10
10
7
5
4
2
1
1
1
Options
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Catalog No. ABIN671776
$ 427.90
Plus shipping costs $45.00

General

Antigen Fibroblast Growth Factor Receptor 4 (FGFR4) Antibodies
Epitope AA 40-90
(18), (16), (15), (10), (10), (9), (6), (6), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(207), (59), (49), (3), (3)
Host Rabbit
(131), (73), (17)
Clonality
Polyclonal
Conjugate This FGFR4 antibody is conjugated to PE
(9), (8), (6), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(166), (105), (63), (40), (34), (29), (13), (10), (10), (7), (5), (4), (2), (1), (1), (1)
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Product Details anti-FGFR4 Antibody

Target Details FGFR4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human FGFR4
Isotype IgG

Target Details FGFR4

Product Details anti-FGFR4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name FGFR4/CD334 (FGFR4 Antibody Abstract)
Background

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Subcellular location: Extracellular


Synonyms: TKF, JTK2, CD334, Fibroblast growth factor receptor 4, FGFR-4, FGFR4
Gene ID 2264
UniProt P22455
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding

Application Details

Product Details anti-FGFR4 Antibody Target Details FGFR4 Handling Images back to top
Application Notes FCM(1:20-100)
Comment

Exitation/Emission: 480,565nm/578nm

Restrictions For Research Use only

Handling

Product Details anti-FGFR4 Antibody Target Details FGFR4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at 4°C
Expiry Date 12 months