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Human Galectin 3 Protein expressed in Human Cells - ABIN2215866
Hou, Cao, Li, Wang, Pei, Wang, Pei: One-step synthesis of dual clickable nanospheres via ultrasonic-assisted click polymerization for biological applications. in ACS applied materials & interfaces 2014
Demonstrate that galectin-3 plays a critical role in hensin (show DMBT1 Proteins) ECM (show MMRN1 Proteins) assembly by oligomerizing secreted monomeric hensin (show DMBT1 Proteins).
Available experimental binding affinities for a small number of the tested compounds show very good agreement with the calculated energies and provide the rational approach for design of Gal-3 ligands with even higher affinity.
An interruption of O-glycans extension caused by ST6GalNAc-I (show ST6GALNAC1 Proteins) enzymatic activity alters galectin-3 subcellular location, leading to gastric tumor cell resistance to chemotherapeutic drugs.
Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNgamma and glycoproteins of the tumour extracellular matrix, thus avoiding IFNgamma diffusion and the formation of an IFNgamma-induced chemokine (show CCL1 Proteins) gradient required for T cell infiltration.
this study identified 131 Gal-3 and 15 Gal-1 (show LGALS1 Proteins) interactors by galectin pulldown experiments combined with quantitative proteomics.
Evaluation of galectin-7 (show LGALS7 Proteins) could help guide postsurgical management for non-metastatic ccRCC patients.
The aim of this study was to investigate the association between myocardial fibrosis and plasma galectin-3 level in patients with primary aldosteronism.
We have validated the vectors and confirmed self-association of AHCY (show AHCY Proteins), AHCYL1 (show AHCYL1 Proteins), and galectin-3. In a high-throughput BiFC screen, we identified new AHCY (show AHCY Proteins) interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY (show AHCY Proteins)-galectin-3 interaction
this study demonstrated that increased galectin-3 level was an independent unfavorable factor for OS in patients with non-M3 AML (show RUNX1 Proteins).
Our results indicate that the nuclear expression of Gal-3 has an essential role in the development of chromophobe carcinoma. The association with advanced tumor stage and nuclear grade suggests that this protein is an indicator of aggressiveness in the chromophobe subtype, thus targeting anti-nuclear transport may prove an effective therapy for this particular group of patients.
regulation of gal-3 expression was strongly correlated with runx2 (show RUNX2 Proteins) transcription factor in human thyroid carcinoma.
Mutational tuning of galectin-3 specificity and biological function.
The overall findings suggest that the secreted galectin-3 stimulated by PGF (show PGF Proteins) plays a role in structural luteolysis by binding to beta 1 integrin.
The relative abundance of PIBF (show PIBF1 Proteins), LGALS1 (show LGALS1 Proteins), LGALS3 (show LGALS2 Proteins), LGALS3BP (show LGALS3BP Proteins), and LGALS9 (show LGALS9 Proteins) mRNA would display a differential expression pattern in the endometrium.
Galectin-3-positive macrophages in all tissues bovine female reproductive organs are involved in either cell survival or death.
These findings suggest that galectin-3 expression plays a role in the maturation and activation of sperm in bulls.
galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis
Lgals3, a PRC2 target gene encoding a multifunctional galactose-binding lectin, was derepressed in I363M heterozygotes, which enhanced the stemness of HSPCs. Thus, our work provides in vivo evidence that the structural integrity of EED (show EED Proteins) to H3K27me3 propagation is critical, especially for embryonic development and hematopoietic homeostasis, and that its perturbation increases the predisposition to hematologic malignancies.
Increased galectin-3 levels are associated with abdominal aortic aneurysm progression. Galectin-3 inhibition with modified citrus pectin prevented AAA (show AAAS Proteins) development.
Data suggest that different patterns of Pkd1 (show PKD1 Proteins)-deficiency can lead to cardiac dysfunction and that galectin-3 has a role in intensifying this phenotype and limiting survival, effects potentially applicable to human autosomal dominant polycystic kidney disease.
This study reveals a uniquely regulated inflammatory response in the SVZ and shows that Gal-3 participates in remyelination in the cuprizone model.
Data demonstrated that the absence of host galectin-3 drastically affected the tumor biology favoring the metastatic spreading of 4T1 cells to inguinal lymph nodes and bone marrow colonization.
study demonstrated that endogenous Gal-3 is specifically involved in leukocyte slow rolling
Gal-3 influences remyelination by mechanisms involving the tuning of microglial cells, modulation of MMP activity, and changes in myelin architecture.
These data indicate a role for endogenous Gal-3 in neutrophil clearance during acute inflammation.
Our results suggest that endogenous galectin-3 regulates Notch (show NOTCH1 Proteins) signaling activation in bone marrow-derived dendritic cells and influences polarization of T helper responses
Results suggest that prion protein PrPC (show PRNP Proteins) combined with galectin-3 and -6 can act as a receptor for murine leukemia virus (MuLV).
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.
35 kDa lectin
, beta-galactosides-binding lectin
, carbohydrate-binding protein 35
, galactose-specific lectin 3
, igE-binding protein
, laminin-binding protein
, lectin L-29
, lectin, galactoside-binding, soluble, 3 (galectin 3)
, mac-2 antigen
, 3 (galectin 3)
, CBP 35
, IgE-binding protein
, MAC-2 antigen
, lectin, galactoside-binding, soluble, 3
, galectin 3
, IgE binding protein
, lectin, galactose binding, soluble 3
, L-34 galactoside-binding lectin