anti-Human KIT Ligand antibody for Biochemical Assay

Recommended KIT Ligand Antibody (supplied by: Log in to see )

Antigen
KIT Ligand (KITLG) Antibodies
  • Xkl-1
  • Xsl
  • Xsl-1
  • Xsl-2
  • steel
  • KITLG
  • SCF
  • kitl
  • kl-1
  • mgf
  • scf
  • FPH2
  • KL-1
  • Kitl
  • MGF
  • SF
  • SHEP7
  • Clo
  • Con
  • Gb
  • Kitlg
  • Mgf
  • SLF
  • Sl
  • blz
  • contrasted
  • 710-712
  • CSF
  • KITL
  • KIT ligand L homeolog
  • KIT ligand
  • kit ligand
  • kitlg.L
  • KITLG
  • kitlg
  • Kitl
  • Kitlg
Reactivity
Human, Mouse (Murine)
214
83
68
5
2
2
2
2
2
2
1
1
1
1
1
Host
Mouse
213
60
23
1
Clonality
Monoclonal
Conjugate
This KIT Ligand antibody is un-conjugated
39
13
10
9
9
7
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
247
157
49
38
31
29
26
23
15
13
11
9
4
4
2
2
2
1
1
1
1
1
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Pubmed
6 references available

Available images

Western Blotting (WB) image for anti-KIT Ligand (KITLG) antibody (ABIN2665356)
Catalog No. ABIN2665356
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General

Antigen KIT Ligand (KITLG) Antibodies
Reactivity Human, Mouse (Murine)
(214), (83), (68), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Host Mouse
(213), (60), (23), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This KIT Ligand antibody is un-conjugated
(39), (13), (10), (9), (9), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(247), (157), (49), (38), (31), (29), (26), (23), (15), (13), (11), (9), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-KIT Ligand Antibody

Target Details KIT Ligand Application Details Handling References for anti-KIT Ligand antibody (ABIN2665356) Images
Purification The antibody was purified by affinity chromatography.
Clone L061D3
Isotype IgG1 kappa

Target Details KIT Ligand

Product Details anti-KIT Ligand Antibody Application Details Handling References for anti-KIT Ligand antibody (ABIN2665356) Images back to top
Antigen
Alternative Name SCF (KITLG Antibody Abstract)
Background Stem Cell Factor (SCF) is initially synthesized as membrane-bound forms of 248 or 220 amino acids, depending on the alternative splicing of exon 6. The 248 amino acid form contains a proteolytic cleavage site encoded by exon 6, and it is cleaved from the cell to release an active soluble protein of 165 amino acid residues. Soluble SCF is glycosylated at both N-linked and O-linked sites. MMP-9 plays a physiological role in SCF release from the membrane, and this action plays a significant role in differentiating and mobilizing stem and progenitor cells from the bone marrow. SCF increases the proliferation of myeloid and lymphoid hematopoietic progenitors in bone marrow cultures. SCF/c-kit interaction in mast cells results in mast cell degranulation that induces the release of mediators, such as histamine and inflammatory cytokines and chemokines. Also, activation of c-kit in dendritic cells regulates T helper cell differentiation and allergic asthma. In addition, SCF plays an important role in revascularization of ischemic limbs. Ischemia induces plasma elevation of SCF, thrombopoietin (TPO), erythropoietin (EPO), and GM-CSF albeit at lower levels. SCF and TPO induce the release of CXCL12 from platelets, which increase CXCL12 levels in plasma. This results in an extensive mobilization of CXCR4+VEGFR1+ cells (hemangiocytes) that accelerate revascularization of the ischemic limbs. SCF binds to its receptor c-kit, which belongs to the type III tyrosine kinase family whose members include receptors for M-CSF and PDGF.
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-KIT Ligand Antibody Target Details KIT Ligand Handling References for anti-KIT Ligand antibody (ABIN2665356) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-KIT Ligand Antibody Target Details KIT Ligand Application Details References for anti-KIT Ligand antibody (ABIN2665356) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-KIT Ligand antibody (ABIN2665356)

Product Details anti-KIT Ligand Antibody Target Details KIT Ligand Application Details Handling Images back to top
Background publications

Ray, Krishnamoorthy, Oriss, Ray: "Signaling of c-kit in dendritic cells influences adaptive immunity." in: Annals of the New York Academy of Sciences, Vol. 1183, pp. 104-22, 2010

Krishnamoorthy, Oriss, Paglia, Fei, Yarlagadda, Vanhaesebroeck, Ray, Ray: "Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma." in: Nature medicine, Vol. 14, Issue 5, pp. 565-73, 2008

Jin, Shido, Kopp, Petit, Shmelkov, Young, Hooper, Amano, Avecilla, Heissig, Hattori, Zhang, Hicklin, Wu, Zhu, Dunn, Salari, Werb, Hackett, Crystal, Lyden, Rafii: "Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes." in: Nature medicine, Vol. 12, Issue 5, pp. 557-67, 2006

Rönnstrand: "Signal transduction via the stem cell factor receptor/c-Kit." in: Cellular and molecular life sciences : CMLS, Vol. 61, Issue 19-20, pp. 2535-48, 2004

Heissig, Hattori, Dias, Friedrich, Ferris, Hackett, Crystal, Besmer, Lyden, Moore, Werb, Rafii: "Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand." in: Cell, Vol. 109, Issue 5, pp. 625-37, 2002

Lu, Jones, Shieh, Mendiaz, Feng, Watler, Narhi, Langley: "Isolation and characterization of a disulfide-linked human stem cell factor dimer. Biochemical, biophysical, and biological comparison to the noncovalently held dimer." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11309-16, 1996

Images

Product Details anti-KIT Ligand Antibody Target Details KIT Ligand Application Details Handling References for anti-KIT Ligand antibody (ABIN2665356) back to top
Supplier Images
Western Blotting (WB) image for anti-KIT Ligand (KITLG) antibody (ABIN2665356) anti-KIT Ligand (KITLG) antibody