|Antigen||Neuregulin 2 (NRG2) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Neuregulin 2 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-Neuregulin 2 AntibodyTarget Details Neuregulin 2 Application Details Handling Images
|Specificity||Specific for NRG2.|
|Immunogen||A synthetic peptide from extracellular domain of mouse Neuregulin-2 (NRG2) conjugated to an immunogenic carrier protein was used as the antigen.|
Target Details Neuregulin 2Product Details anti-Neuregulin 2 Antibody Application Details Handling Images back to top
|Alternative Name||Neuregulin 2 (NRG2 Antibody Abstract)|
Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Subcellular location: Pro-neuregulin-2, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein. Note: Does not seem to be active. Neuregulin-2: Secreted
Tissue specificity: Expressed in most parts of the brain, especially theolfactory bulb and cerebellum where it localizes in granule and Purkinje cells. In the hippocampus, found in the granule cells of the dentate gyrus. In the basal forebrain, found in the cholinergic cells. In the hindbrain, weakly detectable in the motor trigeminal nucleus. Not detected in the hypothalamus. Also found in the liver and in the thymus. Not detected in heart, adrenal gland, or testis. Also known as: Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin 1, DON-1, NTAK.
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Handling Images back to top
A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|