Mouse anti-Human IgG4 Antibody

Catalog No. ABIN952860

Product Details

Target: IgG4

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Supernatant

Clone: MRQ-44

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Monoclonal antibodies should not be stored at a temperature below -25 °C due to the aggregation effect of the protein.

Target Details

Target: IgG4

Alternative Name: Immunoglobulin G4 (IgG4) (IgG4 Products)

Target Type: Antibody

Background: IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma. Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/ IgG ratios (typically > 30 % ).Synonyms: Human Immunoglobulin G4