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anti-Rat (Rattus) DIAPH1 Antibodies:
anti-Mouse (Murine) DIAPH1 Antibodies:
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Human Polyclonal DIAPH1 Primary Antibody for WB - ABIN153169
Minin, Kulik, Gyoeva, Li, Goshima, Gelfand: Regulation of mitochondria distribution by RhoA and formins. in Journal of cell science 2006
Show all 4 Pubmed References
Human Polyclonal DIAPH1 Primary Antibody for ICC, IF - ABIN153170
Jewett, Fischer, Mead, Hackstadt: Chlamydial TARP is a bacterial nucleator of actin. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 2 Pubmed References
Human Polyclonal DIAPH1 Primary Antibody for IHC, IHC (p) - ABIN4305203
Goel, Sienkiewicz, Picciani, Lee, Bhattacharya: Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. in PLoS ONE 2011
The aim of this study was to investigate the role of DIAPH1 in the physiological response to experimental myocardial I/R in mice. After subjecting wild-type mice to experimental I/R, myocardial DIAPH1 expression was increased, an effect that was echoed following hypoxia/reoxygenation (H/R) in H9C2 and AC16 cells
what was seen for RhoC, mDia1 silencing through RNAi inhibited phagosome formation. Additionally, the coexpression of mDia1 with constitutively active mutant RhoC-G14V or expression of active mutant mDia1-DeltaN3 drastically inhibited the uptake of IgG-Es. These data suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
these results uncover a novel role for mDia1 in Abeta (show APP Antibodies)-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs (show PTMS Antibodies) are driving factors for the induction of tau-mediated neuronal damage.
Small Molecule Inhibition of Ligand-Stimulated RAGE (show AGER Antibodies)-DIAPH1 Signal Transduction.
Diaphanous-related formin (show DIAPH3 Antibodies) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM Antibodies) phenotype.
Liprin-alpha3 (show PPFIA3 Antibodies) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 Antibodies) activation by RhoA (show RHOA Antibodies).
Depleting FMNL1 (show FMNL1 Antibodies), another Formin (show FMN1 Antibodies) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Antibodies) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Antibodies)-mDia1-Profilin1 (show PFN1 Antibodies) signaling pathway in mouse oocytes.
Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 Antibodies) messenger RNA in granulocytes, but not in other lineages.
Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
Diaph1 is highly expressed in glioma, plays a significant role in glioma cell migration, and can influence the expression and activity of MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies).
Data show that diaphanous related formin 1 protein (Dia1 (show CYB5R3 Antibodies)) and diaphanous related formin 2 (show DIAPH2 Antibodies) protein (Dia2 (show DIAPH2 Antibodies)) facilitated HIV-1-induced microtubule (MT) stabilization and the intracellular motility of virus particles.
Down-regulation of mDia1 by infection with an adenovirus encoding siRNA or blockade of RAGE (show AGER Antibodies)-mDia1 binding by transfection with RAGE (show AGER Antibodies) mutant plasmids into HUVECs abolished these AGE-induced effects.
DIAPH1 mutation is associated with Progressive macrothrombocytopenia and hearing loss.
It is therefore noteworthy that we found DIAPH1 expression also in spiral ganglion neurons and in the barrier between the myelinating glia of the peripheral nervous system and oligodendrocytes that form the myelinating glia of the central nervous system (CNS).
mDia1 was recruited to the zonula adherens (ZA) of established Caco-2 monolayers in response to E-cadherin (show CDH1 Antibodies) and RhoA (show RHOA Antibodies).
Actin dynamics and formins control DNA replication by multiple direct and indirect mechanisms.
DIAPH1 interaction with the RAGE (show AGER Antibodies) cytoplasmic domain. [review]
Ligand-induced association of RAGE (show AGER Antibodies) homodimers on the cell surface increases the molecular dimension of the receptor, recruiting DIAPH1 and activating signaling pathways.
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
diaphanous homolog 1 (Drosophila)
, diaphanous homolog 1
, diaphanous homolog 2
, protein diaphanous homolog 1
, protein diaphanous homolog 1-like
, diaphanous-related formin-1