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HOXA1-mediated activation of NF-kappaB (show NFKB1 Proteins) is non-transcriptional and the RBCK1 (show RBCK1 Proteins) and TRAF2 (show TRAF2 Proteins) influences on NF-kappaB (show NFKB1 Proteins) are epistatic to HOXA1
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia (show BCL11A Proteins).
Data indicated that HOXA1 and CCND1 (show CCND1 Proteins) mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells.
In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness.
our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis
Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 (show DNMT1 Proteins) & DNMT3b (show DNMT3B Proteins) expression.
YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes.
Analysis indicates that the genes BIRC5 (show BIRC5 Proteins), HOXA1 and RARB (show RARB Proteins) are critical targets that play an important regulatory role in cervical cancer pathogenesis.
ACK1 (show TNK2 Proteins) interacts with KDM3A (show KDM3A Proteins) to regulate the mammary tumor oncogene (show RAB1A Proteins) HOXA1.
When Hoxa1, Hoxb1 (show HOXB1 Proteins) and Hoxd1 (show HOXD1 Proteins) are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.
Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish.
Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR (show MLXIP Proteins)-30b target in esophageal cancer (EC) cells.
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5 (show HOXA5 Proteins), HoxC4 (show HOXC4 Proteins) &HoxC8 (show HOXC8 Proteins) markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS Proteins) down regulates HoxA10 (show HOXA10 Proteins). T3 results in over expression of HoxA5 (show HOXA5 Proteins), HoxC4 (show HOXC4 Proteins) and HoxC8 (show HOXC8 Proteins) genes, whereas insulin (show INS Proteins) up regulates expression of only HoxC8 (show HOXC8 Proteins)
These data suggest that Hoxb1 (show HOXB1 Proteins) and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking.
Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients.
Hoxa1 acts in a genetic cascade upstream of genes controlling specific aspects of embryonic development.
Hoxa1 lineage tracing uncovered new domains of Hoxa1 expression in rhombomere 3, the otic epithelium, and cardiac precursors, suggesting a more direct role for Hoxa1 in development of these tissues than previously believed.
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4 (show SALL4 Proteins); these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3 (show TCF3 Proteins); Sall4 (show SALL4 Proteins) = spalt-like transcription factor 4 (show TCF4 Proteins))
Data indicate that hox genes hoxb1a and hoxb1b have separate functions in hindbrain development.
Hoxb1b regulates mitotic spindle rotation during the oriented neural keel symmetric mitoses that are required for normal neural tube lumen formation in the zebrafish.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
HOX A1 homeodomain protein
, Hox 1.6-like protein
, homeo box A1
, homeobox 1F
, homeobox protein Hox-1F
, homeobox protein Hox-A1
, lab-like protein
, homeobox A1
, homeobox A1, isoform 1
, early retinoic acid 1
, homeobox protein Hox-1.6
, homeoboxless protein ERA-1-399
, homeotic protein ERA-1-993
, homeobox protein
, homeobox b1b
, homeobox gene A-1
, homeobox protein Hox-B1b