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Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
Study found the common variant rs7713917 in the HOMER1 gene to be significantly associated with suicide attempt in Chinese patient.
Homer 1 rs7713917 gene variant associated with brain structure and function, severity of depression, and antidepressant response in patients affected by a major depressive episode in course of bipolar disorder.
This study demonstrate that altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression.
Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury
Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke.
Resequencing three candidate genes (HOMER1, SLC6A4, and TEF) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.
The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma
The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. [review]
The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3.
these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1.
Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of intrahepatic cholangiocarcinoma.
data suggest that HOMER1 rs4704559 G allele has a protective role for the development of levodopa adverse effects
Polymorphisms of DRD1, DLG4 and HOMER1 are associated with opiate abuse.
Overexpression of HOMER1A reduces neuropathic pain hypersensitivity.
The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells.
This review discusses the association of Homer 1 variants with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, addiction and traumatic brain injury.
HOMER1 encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR activity, and is a novel autism-risk gene.
monitored Homer1 and Homer2 expression and subcellular localization in skeletal muscle biopsies following 60 days of bedrest
This study reported significant associations between different polymorphisms of the HOMER 1 gene and psychopathology of schizophrenic patients at baseline and between HOMER 1 polymorphisms and therapy response after treatment with atypical antipsychotics.
The authors show that SNX6 functions independently of retromer to regulate distribution of Homer1b/c in the dendritic shaft.
All these results showed that Homer1 is involved in t-BHP-induced endothelial dysfunction in mBECs, and may be an ideal candidate for searching gene intervention strategy for preventing endothelial oxidative stress in vitro.
The study showed that Homer1b/c increased in mtSOD1 G93A transgenic mice, which contributes to neuronal apoptosis in amyotrophic lateral sclerosis. The inhibition of Homer1b/c by its siRNA and lithium and valproic acid protected against neuronal apoptosis in amyotrophic lateral sclerosis induced by mtSOD1 G93A.
Homer1a contributes to retinal ganglion cell survival after ischemia/reperfusion injury by interacting with Erk pathway.
Homer1a may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B-PSD95-nNOS complexes and reducing the membrane distribution of NR2B.
This study demonstrated that brain stimulations that induce H1a expression may be beneficial to depression.
Results provide compelling evidence for the involvement of the Homer1/mGluR5 complex in the emergence and regulation of stress-induced behavioral and neuroendocrine phenotypes
Specific siRNA knockdown of homer 1a in medial prefrontal cortex enhanced depressive-like behavior.
Homer 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate receptors.
integrity of Homer scaffolds is essential for normal metabotropic glutamate receptor-evoked endocannabinoid functioning
Deletion of Homer1 leads to a diverging phenotype that either displays an inability to perform the task or outstanding hyperactivity in both learning and motivational sessions.
These data indicate that Homer1c-mGluR5 interactions are necessary for mGluR-dependent long-term potentiation
The regulation of Homer1 splicing by GnRH contributes to gonadotropin gene control.
Homer-1a/Vesl-1S, as a potential target for the prophylaxis and treatment of age-related cognitive decline.
The data of this study provided evidence that in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference in mice.
mGluR5 up-regulation contributed selectively to the apoptosis of astrocytes via the activation of phospholipase C and the release of calcium from intracellular stores as well as via the association with Homer proteins.
This study demonistrated taht the mGluR5/Homer1b/c signaling pathway as a major mediator of stress-induced spatial memory deficits.
deletion of Homer1a in mouse results in failure to sustain long bouts of wakefulness.
These data provide evidence for dynamic epigenetic regulation of Homer1a following BDNF-induced plasticity and during a BDNF-dependent learning process.
Results indicate that miR-3906 controls [Ca(2+)]i homeostasis in fast muscle through fine tuning homer-1b expression during differentiation
The high level of conservation of the xhomer1 gene and the protein expression in the developing nervous system suggest that Homer1 expression may be important for normal neuronal circuit development.
Genetic deletion of Homer in Drosophila results in fragmented sleep and in failure to sustain long bouts of sleep, even under increased sleep drive.
null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and failure to develop normal levels of rapid tolerance
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
homer protein homolog 1
, homer, neuronal immediate early gene, 1
, homer homolog 1 (Drosophila)
, homer 1
, VASP/Ena-related gene up-regulated during seizure and LTP 1
, immediate early gene protein Homer1A
, homer homolog 1
, homer homolog 1b
, scaffold protein
, homer 1b-1
, CG11324 gene product from transcript CG11324-RD
, drosophila Ves-1 homolog