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These studies reveal ZHX2 as a potential therapeutic target for clear cell renal cell carcinoma.
ZHX2 expression in renal cell carcinoma
Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes
These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs.
Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription.
Data indicate that zinc-fingers and homeoboxes 2 (ZHX2) suppresses glypican 3 (GPC3) transcription by binding with its core promoter.
Two novel markers, rs7840785 (PINX1) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness.
simultaneous application of ZFN and rescue DNA induced gene repair of the disease-causing mutation on the genomic level, resulting in recovery of protein expression.
Expression of a constitutively active Raf transgene enhances lymphoproliferation, indicating a role for the Ras-MAPK pathway in linker for activation of T cells (LAT)-mediated autoimmune hyperproliferation.
There was no significant difference in high and low percentage of HbF in GG, GA, and AA bearing individuals showing that ZHX2 gene variant has no role in ameliorating the severity of beta-thalassemia major in the South Indian population from Andhra Pradesh.
results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines
Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2.
identification as a transcriptional repressor
ZHX2, a transcriptional repressor, may participate in globin gene regulation.
ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
High ZHX2 is associated with metastasis in hepatocellular carcinoma.
These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer.
Additional Cyp genes are disregulated in the absence of Zhx2.
NFAT1 protein activation can shift oncogenic Ras/Raf/MEK/ERK signaling to acting as a tumor suppressor pathway.
The Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase, a gene normally silenced in the adult liver.
molecular crosstalk between aberrant expression of Hox molecule(s) and activated Raf may have a key role in the MLL-fusion-mediated-leukemogenesis
Zhx2 acts as a repressor of Gpc3 in the adult liver.
The carboxyl terminus of Angptl4 alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf/MEK/ERK1/2 MAP kinase pathway in endothelial cells.
These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis.
evidence presented that ZHX2 & ephrin-B1 cytoplasmic domain can interact & regulate transcription; study identifies ZHX2 as novel regulator of neural progenitor cell maintenance & suggests potential nuclear mechanism of ephrin-B function in the cortex
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
zinc fingers and homeoboxes 2
, zinc finger and homeodomain protein 2
, zinc fingers and homeoboxes protein 2
, zinc fingers and homeoboxes protein 2-like
, AFP regulator 1
, alpha-fetoprotein regulator 1
, regulator of AFP
, transcription factor ZHX2
, zinc-fingers and homeoboxes 2
, alpha fetoprotein regulation 1, adult