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ZHX2 expression in renal cell carcinoma (show MOK Proteins)
Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes
These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs.
Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (show NFYA Proteins) (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription.
Data indicate that zinc-fingers and homeoboxes 2 (ZHX2) suppresses glypican 3 (GPC3 (show GPC3 Proteins)) transcription by binding with its core promoter.
Two novel markers, rs7840785 (PINX1 (show PINX1 Proteins)) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness.
Expression of a constitutively active Raf (show RAF1 Proteins) transgene enhances lymphoproliferation (show FAS Proteins), indicating a role for the Ras-MAPK (show MAPK1 Proteins) pathway in linker for activation of T cells (LAT (show LAT Proteins))-mediated autoimmune hyperproliferation.
There was no significant difference in high and low percentage of HbF in GG, GA, and AA bearing individuals showing that ZHX2 gene variant has no role in ameliorating the severity of beta-thalassemia major in the South Indian population from Andhra Pradesh.
results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines
Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2.
Additional Cyp (show PPIG Proteins) genes are disregulated in the absence of Zhx2.
NFAT1 (show NFAT1 Proteins) protein activation can shift oncogenic Ras/Raf (show RAF1 Proteins)/MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling to acting as a tumor suppressor pathway.
The Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase (show LPL Proteins), a gene normally silenced in the adult liver.
molecular crosstalk between aberrant expression of Hox (show MSH2 Proteins) molecule(s) and activated Raf (show RAF1 Proteins) may have a key role in the MLL (show MLL Proteins)-fusion-mediated-leukemogenesis
Zhx2 acts as a repressor of Gpc3 (show GPC3 Proteins) in the adult liver.
The carboxyl terminus of Angptl4 (show ANGPTL4 Proteins) alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf (show RAF1 Proteins)/MEK (show MDK Proteins)/ERK1/2 MAP kinase (show MAPK1 Proteins) pathway in endothelial cells.
These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis.
evidence presented that ZHX2 & ephrin-B1 cytoplasmic domain can interact & regulate transcription; study identifies ZHX2 as novel regulator of neural progenitor cell maintenance & suggests potential nuclear mechanism of ephrin-B function in the cortex
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
zinc fingers and homeoboxes 2
, zinc finger and homeodomain protein 2
, zinc fingers and homeoboxes protein 2
, zinc fingers and homeoboxes protein 2-like
, AFP regulator 1
, alpha-fetoprotein regulator 1
, regulator of AFP
, transcription factor ZHX2
, zinc-fingers and homeoboxes 2
, alpha fetoprotein regulation 1, adult