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Cow (Bovine) Polyclonal ARF6 Primary Antibody for IHC, WB - ABIN2785790
Karim, Choi, Whiteheart: Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. in The Journal of biological chemistry 2008
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In Jurkat cells, the activities of two guanine nucleotide binding proteins, Arf6 and Rab22 (show RAB22A Antibodies) (also known as Rab22a (show RAB22A Antibodies)), influence CIE and conjugate formation.
The Arf6 is of particular interest,since it is believed to play a regulatory role in several cellular physiological functions, including cell-cell interactions(adhesiveness), motility, shape maintenance, and responses to environmental stimuli via cytoskeletal adaptations and vesicular trafficking.
computational study suggests that although curcumin to some extent binds with Tp receptor (show TBXA2R Antibodies), yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD (show PLD Antibodies) activity in PASMCs.
This study identifies a novel regulatory crosstalk between Ral (show rala Antibodies) and Arf6 that controls Ral (show rala Antibodies) function in cells.
ARHGAP24 (show ARHGAP24 Antibodies) may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
ARF6 was a downstream target of Kras/ERK (show EPHB2 Antibodies) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (show F3 Antibodies) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (show RAB35 Antibodies) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
accumulation of free cholesterol in late endosomes/lysosomes of Arf6 knockout mouse embryonic fibroblasts results from mistrafficking of Niemann-Pick type C protein NPC2 (show NPC2 Antibodies)
results indicated that Arf6 was involved in mouse oocyte meiosis through its functional roles in actin-mediated spindle movement and spindle organization.
The present study demonstrated that the Arf6-specific GAP ACAP3 (show Acap3 Antibodies) plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex.
Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3 (show IKBKG Antibodies)-dependent trafficking of endosomes containing N-cadherin (show CDH2 Antibodies) during cortical layer formation.
The results show that ARNO (show CYTH2 Antibodies) interaction with the RLIP76 (show RALBP1 Antibodies) N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 (show RALBP1 Antibodies) control of Rac (show AKT1 Antibodies).
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (show DMD Antibodies)-associated glycoprotein complex (DGC (show GGCX Antibodies)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (show GGCX Antibodies).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 (show Acap3 Antibodies) in concert with a guanine-nucleotide-exchange factor (show ARHGEF12 Antibodies)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (show ABCA1 Antibodies) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (show ABCA1 Antibodies) recycling and efflux of intracellular cholesterol.
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP-ribosylation factor 6
, ADP-ribosylation factor-like 6
, ADP-ribosylation factor-like protein 6