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STX8 silencing restores the function ofDeltaF508-CFTR.
Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes.
Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4.
Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
Syntaxin-8 regulates the endocytosis of TASK-1.
These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney.
There are increases in CARB localized to intraneuronal neurofibrillary tangles and granulovacuolar degeneration in susceptible hippocampal and cortical neurons in Alzheimer's disease.
syntaxin 8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery
Has two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes.
Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR.
Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes.
Syntaxin 8 and HECTd3 have similar subcellular localization.
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
, syntaxin 8
, t-SNARE family protein
, CIP-1-associated regulator of cyclin B
, syntaxin-like protein 3I35