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Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes.
Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4 (show SLC2A4 Proteins).
Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
Syntaxin-8 regulates the endocytosis of TASK-1 (show KCNK3 Proteins).
These results suggest that STX8 mediates the recycling of CLDN16 (show CLDN16 Proteins) and constitutes an important component of the CLDN16 (show CLDN16 Proteins) trafficking machinery in the kidney.
syntaxin 8 contributes to the regulation of CFTR (show CFTR Proteins) trafficking and chloride channel (show CLCA1 Proteins) activity by the SNARE (show NAPA Proteins) machinery
Results report that syntaxin 7 (show STX7 Proteins), syntaxin 8, vti1b (show VTI1B Proteins) and VAMP8 (show VAMP8 Proteins) physically and functionally interact with CFTR (show CFTR Proteins).
Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes.
Syntaxin 8 and HECTd3 (show HECTD3 Proteins) have similar subcellular localization.
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
, syntaxin 8
, t-SNARE family protein
, CIP-1-associated regulator of cyclin B
, syntaxin-like protein 3I35