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|Antigen||CD247 Molecule (CD247) Antibodies|
|Epitope||Cytoplasmic Domain Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This CD247 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
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Product Details anti-CD247 AntibodyTarget Details CD247 Application Details Handling Images
|Specificity||The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines. Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events. A novel monoclonal antibody, named 3H2012, has been developed that is specific for the TCR zeta chain subunit (CD247). The antibody is capable of precipitating both non-phosphorylated and tyrosine phosphorylated TCR zeta chain. Species cross-reactivity: Mouse and human.|
|Purification||Protein A purified|
113 Amino acid synthetic peptide corresponding to the cytoplasmic domain of murine zeta.
Type of Immunogen: Synthetic peptide
Target Details CD247Product Details anti-CD247 Antibody Application Details Handling Images back to top
|Alternative Name||CD247 / CD3 Zeta (CD247 Antibody Abstract)|
Name/Gene ID: CD247
Synonyms: CD247, CD3 Zeta, CD3H, CD3Z, CD247 antigen, zeta subunit, CD247 Molecule, CD3zeta chain, T3Z, TCR zeta chain, TCRZ, T-cell receptor T3 zeta chain, CD247 antigen, CD3-ZETA, CD3Q
|Pathways||TCR Signaling, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-CD247 Antibody Target Details CD247 Handling Images back to top
Approved: ELISA (1 μg/mL), Flo (1:50), IHC-Fr, IP (2 μg/mL), WB
Usage: Flow Cytometry: 1:50-1: ELISA: 1 μg/mL. Immunoprecipitation: 2 μg/mL. Western Blot. Immunohistochemistry (frozen).
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD247 Antibody Target Details CD247 Application Details Images back to top
|Buffer||PBS, pH 7.2, 0.1 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeat freeze-thaw cycles.|
|Storage||4 °C,-20 °C|
Long term: -20°C
Short term: +4°C. Avoid repeat freeze-thaw cycles.